29480-13-5

Basic information

• Product Name: 1-(4-(trifluoromethyl)phenyl)cyclohexanol
• Synonyms: 1-(4-(trifluoromethyl)phenyl)cyclohexanol
• CAS NO: 29480-13-5
• Molecular Weight: 244.257
• Mol File: 29480-13-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(4-(trifluoromethyl)phenyl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(trifluoromethyl)phenyl)cyclohexanol(29480-13-5)
• EPA Substance Registry System: 1-(4-(trifluoromethyl)phenyl)cyclohexanol(29480-13-5)

Safety Data

• Hazardous Substances Data: 29480-13-5(Hazardous Substances Data)

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 108-94-1 cyclohexanone 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 

Downstream Products

• 74975-88-5 4'-(trifluoromethyl)-2,3,4,5-tetrahydro-1,1'-biphenyl 
• 29480-00-0 1-(1-Chloro-cyclohexyl)-4-trifluoromethyl-benzene 
• 455-24-3 4-trifluoromethylbenzoic acid 

Relevant articles and documents

Electrophotochemical Ring-Opening Bromination oftert-Cycloalkanols

An electrophotochemical ring-opening bromination of unstrainedtert-cycloalkanols has been developed. This electrophotochemical method enables the oxidative transformation of cycloalkanols with 5- to 7-membered rings into synthetically useful ω-bromoketones without the use of chemical oxidants or transition-metal catalysts. Alkoxy radical species would be key intermediates in the present transformation, which generate through homolysis of the O-Br bond in hypobromite intermediates under visible light irradiation.

Iodine-Promoted Metal-Free Aromatization: Synthesis of Biaryls, Oligo p-Phenylenes and A-Ring Modified Steroids

We describe efficient procedures based on the use of iodine for the synthesis of biaryls from arylcyclohexenols or arylcyclohexanols using sub-stoichiometric/catalytic iodine and dimethyl sulfoxide (DMSO) as oxidant. Heteroarylcyclohexanols also produced the corresponding biaryl products. It was proven that biphenyl can also be efficiently obtained when the quantity of iodine was reduced to 0.05 equiv. The method is compatible with different functional groups in the aromatic ring (either electron-donating or electron-withdrawing groups). For substrate scope, apart from cyclohexanone and cyclohexenone, some substituted cyclohexanones were also used to synthesize the starting arylcyclohexanols. The process was applied to the synthesis of oligo p-phenylenes and A-ring aromatized steroids, where the combined use of I2/DMSO not only provoked the necessary migration of the methyl group at C-10, but also further extended the conjugation.

4'-Fluoro-4-{[4-(phenyl)-4-alkoxy-cyclo-hexyl]amino}butyrophenones and the salts thereof

This invention relates to novel 4-(substituted alkoxy)-4-(substituted phenyl)cyclohexylamines embraced by the formula SPC1 Wherein ? is a generic expression denoting cis and trans stereoconfiguration and mixtures thereof, with the proviso that when the st