29481-26-3

Basic information

• Product Name: 5-cyclopropyl-2-thiophenecarboxaldehyde
• Synonyms: 5-cyclopropyl-2-thiophenecarboxaldehyde;5-cyclopropylthiophene-2-carbaldehyde
• CAS NO: 29481-26-3
• Molecular Formula: C₈H₈OS
• Molecular Weight: 152.21352
• Mol File: 29481-26-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-cyclopropyl-2-thiophenecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyclopropyl-2-thiophenecarboxaldehyde(29481-26-3)
• EPA Substance Registry System: 5-cyclopropyl-2-thiophenecarboxaldehyde(29481-26-3)

Safety Data

• Hazardous Substances Data: 29481-26-3(Hazardous Substances Data)

Upstream product

• 7283-96-7 5-Chloro-2-thiophenecarboxaldehyde 
• 1065010-87-8 potassium cyclopropyltrifluoroborate 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 411235-57-9 cyclopropylboronic acid 

Relevant articles and documents

Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms

We describe the research that led to the discovery of compound 40 (ruzasvir, MK-8408), a pan-genotypic HCV nonstructural protein 5A (NS5A) inhibitor with a "flat" GT1 mutant profile. This NS5A inhibitor contains a unique tetracyclic indole core while maintaining the imidazole-proline-valine Moc motifs of our previous NS5A inhibitors. Compound 40 is currently in early clinical trials and is under evaluation as part of an all-oral DAA regimen for the treatment of chronic HCV infection.

THIOPHENE- SUB STITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

Disclosed are novel Thiophene-Subsituted Tetracyclic Compounds of Formula (I). And pharmaceutically acceptable salts thereof, wherein A, A', R2, R3, R4 and R5 are as defined herein. The compositions comprising at least one Thiophene-Subsituted Tetracyclic Compounds, and methods of using the Thiophene-Subsituted Tetracyclic Compounds for treating or preventing HCV infection in a patient are also disclosed.

Cross-coupling of cyclopropyl- and cyclobutyltrifluoroborates with aryl and heteroaryl chlorides

(Chemical Equation Presented) Suitable conditions were found for the Suzuki-Miyaura cross-coupling reaction of potassium cyclopropyl-and cyclobutyltrifluoroborates with aryl chlorides. Both of these secondary alkyl trifluoroborates coupled in moderate to excellent yield with electron-rich, electron-poor, and hindered aryl chlorides to give a variety of substituted aryl cyclopropanes and cyclobutanes.