294852-03-2Relevant articles and documents
New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site
Moss, Neil,Breitfelder, Steffen,Betageri, Raj,Cirillo, Pier F.,Fadra, Tazmeen,Hickey, Eugene R.,Kirrane, Thomas,Kroe, Rachel R.,Madwed, Jeffrey,Nelson, Richard M.,Pargellis, Christopher A.,Qian, Kevin C.,Regan, John,Swinamer, Alan,Torcellini, Carol
, p. 4242 - 4247 (2008/02/09)
Discovery of the pyrazole-naphthyl urea class of p38 MAP kinase inhibitors typified by the clinical candidate BIRB 796 has encouraged further exploration of this particular scaffold. Modification to the part of the inhibitor that occupies the adenine/ATP
Compounds useful as anti-inflammatory agents
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, (2008/06/13)
Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.