294866-41-4

Usage

Uses

Used in Pharmaceutical Industry:
L-2-(4-BROMOPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID is used as a starting material or intermediate in the synthesis of pharmaceutical compounds for its potential biological activity and unique structural features that can be leveraged in drug development.
Used in Medicinal Chemistry Research:
L-2-(4-BROMOPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID serves as a research tool in medicinal chemistry, where its properties and interactions with biological targets are studied to understand its potential as a therapeutic agent.
Used in Organic Synthesis:
L-2-(4-BROMOPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID is used as a building block in organic synthesis for creating more complex molecules with specific applications in various chemical and industrial processes.
Used in Chemical Processes:
Its unique chemical structure makes it a candidate for use in chemical processes where specific reactivity or selectivity is required, potentially leading to the development of new materials or chemical intermediates.

InChI:InChI=1/C10H10BrNO2S/c11-7-3-1-6(2-4-7)9-12-8(5-15-9)10(13)14/h1-4,8-9,12H,5H2,(H,13,14)

Upstream product

• 52-90-4 L-Cysteine 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 1188543-76-1 (4R)-2-(4-bromophenyl)-3-(tert-butoxycarbonyl)thiazolidine-4-carboxylic acid 
• 110078-93-8 (2S,4R)-3-Acetyl-2-(4-bromo-phenyl)-thiazolidine-4-carboxylic acid 
• 110078-82-5 (2R,4R)-3-Acetyl-2-(4-bromo-phenyl)-thiazolidine-4-carboxylic acid 

Relevant academic research and scientific papers

Discovery of cysteine and its derivatives as novel antiviral and antifungal agents

Based on the structure of the natural product cysteine, a series of thiazolidine-4-carboxylic acids were designed and synthesized. All target compounds bearing thiazolidine-4-carboxylic acid were characterized by1 H-NMR,13 C-NMR, and

Synthesis, characterization and antibacterial activities of N-tert-butoxycarbonyl-thiazolidine carboxylic acid

A possible mechanism of dynamic kinetic resolution by the formation of N-tert-butoxycarbonyl-thiazolidine carboxylic acid was proposed and validated by a quantitative density functional theoretical calculation according to Curtin-Hammett principle. Such a

Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents

Nine 2-arylthiazolidine-4-carboxylic acid derivatives and nine 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives were synthesized to screen for their antibacterial activities. Compounds 5, 14-18 were first reported. Their chemical str

Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer

To improve the selectivity and antiproliferative activity of previously reported serine amide phosphates (SAPs), we designed a new series of 4-thiazolidinone amides, in which the 4-thiazolidinone moiety was introduced as a phosphate mimic. However, these 4-thiazolidinone derivatives demonstrated less cytotoxicity in prostate cancer cells despite improved selectivity over RH7777 cells. To further optimize the thiazolidinone analogues in terms of cytotoxicity and selectivity, we made closely related structural modifications, which led us to the discovery of a new class of 2-arylthiazolidine-4-carboxylic acid amides. These compounds were potent cytotoxic agents with IC50 values in the low micromolar concentration range and demonstrated enhanced selectivity in receptor-negative cells compared to SAPs and 4-thiazolidinone amides.

Synthesis and Chiroptical Properties of N-Acetyl-2-aryl-4-thiazolidinecarboxylic Acids

(4R)-2-Aryl-4-thiazolidinecarboxylic acids 3, derived from aromatic aldehydes 1 and L-cysteine (2), could be diastereoselectively converted into (2R,4R)- or (2S,4R)-N-acetyl-2-aryl-4-thiazolidinecarboxylic acids (4 and 5, resp.).The diastereomers can be d