294875-43-7

Upstream product

• 78605-60-4 2-hydroxy-2-(trifluoromethyl)chroman-4-one 
• 151668-40-5 2-trifluoromethyl-4-chromone 
• 869985-98-8 2-trifluoromethyl-4H-chromene-4-thione 
• 869986-20-9 2-trifluoromethyl-4H-chromen-4-one oxime 

Downstream Products

• 312505-97-8 2-(5-trifluoromethyl-isoxazol-3-yl)-phenol 

Relevant academic research and scientific papers

Synthesis and reactivity of 2-polyfluoroalkylchromene-4(4H)-thiones

2-Polyfluoroalkylchromene-4(4H)-thiones, synthesized from 2-polyfluoroalkylchromones and P2S5, react with aniline, phenylhydrazines, and hydroxylamine at the C(4) atom and afford corresponding anils, phenylhydrazones, and oximes of c

2-Polyfluoroalkylchromones 10. Synthesis of regioisomeric 3-(2-hydroxyaryl)-5-polyfluoroalkyl- and 5-(2-hydroxyaryl)-3-polyfluoroalkylisoxazoles and determination of their structures by 1H, 19F, and 13C NMR spectroscopy

The reactions of 2-hydroxy-2-polyfluoroalkylchroman-4-ones with hydroxylamine yield, through Δ2-isoxazolines as intermediate products, 3-(2-hydroxyaryl)-5-polyfluoroalkylisoxazoles. Analogous reactions with 2-polyfluoroalkylchromones afford β-diketone monooximes, which in an acidic medium undergo cyclodehydration into 5-(2-hydroxyaryl)-3-polyfluoroalkylisoxazoles. The structures of regioisomeric 3- and 5-polyfluoroalkylisoxazoles were determined using 1H, 19F, and 13C NMR spectroscopy.