294885-34-0

Basic information

• Product Name: 2-Oxa-3,6,9-triazadecan-10-oic acid, 3-methyl-8-(2-methylpropyl)-4,7-dioxo-5-(2-phenylethyl)-, phenylmethyl ester, (5S,8S)-
• CAS NO: 294885-34-0
• Molecular Formula: C26H35N3O5
• Molecular Weight: 469.581
• Mol File: 294885-34-0.mol

Chemical Properties

• CAS DataBase Reference: 2-Oxa-3,6,9-triazadecan-10-oic acid, 3-methyl-8-(2-methylpropyl)-4,7-dioxo-5-(2-phenylethyl)-, phenylmethyl ester, (5S,8S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxa-3,6,9-triazadecan-10-oic acid, 3-methyl-8-(2-methylpropyl)-4,7-dioxo-5-(2-phenylethyl)-, phenylmethyl ester, (5S,8S)-(294885-34-0)
• EPA Substance Registry System: 2-Oxa-3,6,9-triazadecan-10-oic acid, 3-methyl-8-(2-methylpropyl)-4,7-dioxo-5-(2-phenylethyl)-, phenylmethyl ester, (5S,8S)-(294885-34-0)

Safety Data

• Hazardous Substances Data: 294885-34-0(Hazardous Substances Data)

Upstream product

• 1256776-43-8 2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 1256776-36-9 2-(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoylamino)-4-phenylbutanoic acid methyl ester 

Downstream Products

• 1102143-04-3 benzyl 1-(2-oxo-1-phenoxy-5-phenylpentan-3-ylcarbamoyl)-3-methylbutylcarbamate 
• 1256776-28-9 C₃₆H₄₈N₂O₇ 
• 1256776-32-5 C₃₇H₅₀N₂O₇ 

Relevant articles and documents

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: Toward combination chemotherapy of malaria through a single chemical entity

We extend our approach of combination chemotherapy through a single prodrug entity (O'Neill et al. Angew. Chem., Int. Ed. 2004, 43, 4193) by using a 1,2,4-trioxolane as a protease inhibitor carbonyl-masking group. These molecules are designed to target the malaria parasite through two independent mechanisms of action: iron(II) decomposition releases the carbonyl protease inhibitor and potentially cytotoxic C-radical species in tandem. Using a proposed target "heme", we also demonstrate heme alkylation/carbonyl inhibitor release and quantitatively measure endoperoxide turnover in parasitized red blood cells.