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Guanfacine hydrochloride, also known as guanfacine HCL, is a medication that belongs to the class of alpha-2 adrenergic agonists. It is used to treat attention deficit hyperactivity disorder (ADHD) and high blood pressure by affecting certain neurotransmitters in the brain and the central nervous system. Guanfacine HCL helps improve ADHD symptoms by increasing attention and reducing impulsivity and hyperactivity, while also lowering blood pressure by relaxing and widening blood vessels, facilitating easier blood flow by the heart.

29520-14-7

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29520-14-7 Usage

Uses

Used in Pharmaceutical Industry:
Guanfacine HCL is used as a medication for the treatment of attention deficit hyperactivity disorder (ADHD) for its ability to increase attention and reduce impulsivity and hyperactivity in affected individuals.
Guanfacine HCL is also used as an antihypertensive agent for the management of high blood pressure, working by relaxing and widening blood vessels to ease the heart's pumping effort.
Common side effects associated with the use of guanfacine HCL include drowsiness, dry mouth, and dizziness. It is essential to exercise caution when using this medication in individuals with certain medical conditions such as liver or kidney disease, as these conditions may affect the drug's metabolism and excretion.

Check Digit Verification of cas no

The CAS Registry Mumber 29520-14-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,5,2 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 29520-14:
(7*2)+(6*9)+(5*5)+(4*2)+(3*0)+(2*1)+(1*4)=107
107 % 10 = 7
So 29520-14-7 is a valid CAS Registry Number.

29520-14-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Carbamimidoyl-2-(2,6-dichlorophenyl)-acetamide hydrochloride

1.2 Other means of identification

Product number -
Other names GUANFACINE HYDROCHLORIDE SALT

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:29520-14-7 SDS

29520-14-7Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS

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Paragraph 0538; 0539, (2018/08/30)

The invention provides compounds of formula Ia′, Ib′, Ic′, and Id′: and pharmaceutically acceptable salts thereof, wherein the variables A, R6, R7, R8, R9, Rx, L, X, Y, and Z have the meaning as described herein. The compounds are useful for reducing endoplasmic reticulum stress and for producing analgesia in an animal.

The preparation method of the overall tablet sizes hydrochloride (by machine translation)

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Paragraph 0027; 0028; 0029, (2017/08/29)

The invention discloses a method for preparing the acid salt of the overall tablet sizes. In order to 2, 6 - dichloro acetic acid and methoxy isourea hydrochloride as the starting material, by catalytic condensation, aminolysis, salt, purifying to obtain the hydrochloric acid overall tablet sizes. The preparation method of mild reaction conditions, the operation is simple, compared with the prior art, reduce the operation step, reducing the total reaction time, reduce energy consumption, pollution is smaller, is beneficial to the environment. (by machine translation)

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