295338-33-9Relevant academic research and scientific papers
Discovery of a tetrazole-based growth hormone secretagogue: 4-(Hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)
Li, Jun,Chen, Stephanie Y.,Li, James J.,Wang, Haixia,Hernandez, Andres S.,Tao, Shiwei,Musial, Christa M.,Qu, Fucheng,Swartz, Stephen,Chao, Sam T.,Flynn, Neil,Murphy, Brian J.,Slusarchyk, Dorothy A.,Seethala, Ramakrishna,Yan, Mujing,Sleph, Paul,Grover, Gary,Smith, Mark A.,Beehler, Blake,Giupponi, Leah,Dickinson, Kenneth E.,Zhang, Hongjian,Humphreys, William G.,Patel, Bharat P.,Schwinden, Mark,Stouch, Terry,Cheng, Peter T. W.,Biller, Scott A.,Ewing, William R.,Gordon, David,Robl, Jeffrey A.,Tino, Joseph A.
, p. 5890 - 5893 (2007)
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into
