29569-30-0 Usage
Description
5-Carbamoylmethyluridine, also known as 5-Uridineacetamide, is a modified nucleoside belonging to the class of uridines. It is uridine in which the hydrogen at position 5 of the pyrimidine ring is substituted by a 2-amino-2-oxoethyl group. This modification makes it a putative cancer biomarker, indicating its potential role in cancer research and therapeutics.
Uses
Used in Cancer Research and Diagnosis:
5-Carbamoylmethyluridine is used as a biomarker for cancer, particularly due to its potential association with various types of cancer. Its presence in biological samples can help in the early detection, diagnosis, and monitoring of cancer progression.
Used in Pharmaceutical Development:
5-Carbamoylmethyluridine is used as a key component in the development of novel pharmaceuticals targeting cancer cells. Its unique structure allows for the design of drugs that can specifically interact with cancer-related biological pathways, potentially leading to more effective treatments with fewer side effects.
Used in Drug Delivery Systems:
Similar to gallotannin, 5-carbamoylmethyluridine can also be employed in the development of drug delivery systems. These systems can enhance the delivery, bioavailability, and therapeutic outcomes of drugs targeting cancer cells, by encapsulating 5-carbamoylmethyluridine or its derivatives within organic or metallic nanoparticles.
Check Digit Verification of cas no
The CAS Registry Mumber 29569-30-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,5,6 and 9 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 29569-30:
(7*2)+(6*9)+(5*5)+(4*6)+(3*9)+(2*3)+(1*0)=150
150 % 10 = 0
So 29569-30-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N3O7/c12-6(16)1-4-2-14(11(20)13-9(4)19)10-8(18)7(17)5(3-15)21-10/h2,5,7-8,10,15,17-18H,1,3H2,(H2,12,16)(H,13,19,20)/t5-,7-,8-,10-/m1/s1
29569-30-0Relevant articles and documents
Isolation and characterization of 5-carbamoylmethyluridine and 5- carbamoylmethyl-2-thiouridine from human urine
Chheda,Patrzyc,Tworek,Dutta
, p. 2155 - 2173 (1999)
Two new modified uracil nucleosides, 5-carbamoylmethyuridine (ncm5U, I) and 5-carbamoylmethyl-2-thiouridine (ncm5s2U, II) were isolated from a 24 hr collection of a normal human urine. The structures were assigned on the basis of UV, NMR and mass spectral data and confirmed by comparison of the spectral data and HPLC mobilities with those of authentic samples. On the basis of experimental data it appears possible that 5-carbamoylmethyl- 2-thio-uridine (ncm5s2U, II) may be a degradation product produced from a labile precursor by the chemical treatments during the isolation procedure. However, the other nucleoside (ncm5U,I) certainly appears to be of metabolic origin and was also found in the urines of one chronic myelogenous leukemia and one lung carcinoma patient.
ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
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Page/Page column 633; 634, (2016/06/28)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
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Page/Page column 293, (2014/07/07)
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.