29569-30-0Relevant articles and documents
Isolation and characterization of 5-carbamoylmethyluridine and 5- carbamoylmethyl-2-thiouridine from human urine
Chheda,Patrzyc,Tworek,Dutta
, p. 2155 - 2173 (1999)
Two new modified uracil nucleosides, 5-carbamoylmethyuridine (ncm5U, I) and 5-carbamoylmethyl-2-thiouridine (ncm5s2U, II) were isolated from a 24 hr collection of a normal human urine. The structures were assigned on the basis of UV, NMR and mass spectral data and confirmed by comparison of the spectral data and HPLC mobilities with those of authentic samples. On the basis of experimental data it appears possible that 5-carbamoylmethyl- 2-thio-uridine (ncm5s2U, II) may be a degradation product produced from a labile precursor by the chemical treatments during the isolation procedure. However, the other nucleoside (ncm5U,I) certainly appears to be of metabolic origin and was also found in the urines of one chronic myelogenous leukemia and one lung carcinoma patient.
ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
-
Page/Page column 625; 626, (2016/06/15)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
-
Page/Page column 633; 634, (2016/06/28)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
Alternative nucleic acid molecules and uses thereof
-
Paragraph 2179; 2185, (2015/11/09)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
-
Page/Page column 293, (2014/07/07)
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
LITHIATION OF 5,6-DIHYDROURIDINE: A NEW ROUTE TO 5-SUBSTITUTED URIDINES
Hayakawa, Hiroyuki,Tanaka, Hiromichi,Miyasaka, Tadashi
, p. 1675 - 1684 (2007/10/02)
2',3'-O-Isopropylidene-5'-O-methoxymethyl-5,6-dihydrouridine (2) was found to serve as an "amide α-anion" upon lithiation with LDA.Reactions of the anion with acid chlorides followed by phenylselenation and oxidative elimination furnished 5-acyluridines.For the preparation of 5-alkyluridines, initial introduction of phenylselenenyl group at the C-5 of 2 appeared to be effective.Alkylation of its α-selenenyl carbanion and subsequent generation of 5,6-double bond produced 5-alkyluridines.These routes constitute a new entry to 5-substituted uridines.
Novel C-C Bond Formation at the 5-Position of Uracils. Facile Synthesis of 5-Methoxycarbonylmethyluridine and 5-Carbamoylmethyluridine, Minor Component Nucleosides derived from transfer Ribonuclease
Hirota, Kosaku,Suematsu, Morio,Kuwabara, Yoshitaka,Asao, Tetsuji,Senda, Shigeo
, p. 623 - 624 (2007/10/02)
5-Hydroxyuracil derivatives were treated with stable Wittig reagents to give the corresponding 5-alkyluracil derivatives such as 5-methoxycarbonylmethyluridine and 5-carbamoylmethyluridine.
