38821-11-3Relevant academic research and scientific papers
COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION
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, (2021/06/26)
The invention provides cereblon binders for the degradation of proteins by the ubiquitin proteasome pathway for therapeutic applications.
Strong deshielding in aromatic isoxazolines
Ungvarská Ma?u?ká, Lucia,Vilková, Mária,Ko?í?ek, Jozef,Imrich, Ján
, p. 17 - 27 (2015/12/26)
Very strong proton deshielding was found in di/tri-aromatic isoxazoline regioisomers prepared from acridin-4-yl dipolarophiles and stable benzonitrile oxides (BNO). Three alkenes, (acridin-4-yl)-CH=CH-R (R = COOCH3, Ph, and CONH2), r
Syntheses of highly functionalised 6-substituted pteridines.
Guiney, Donie,Gibson, Colin L,Suckling, Colin J
, p. 664 - 675 (2007/10/03)
Methods for the synthesis of polyfunctional 6-substituted pteridines from the corresponding 6-aldehydes are described. Alkene, ester, ketone, amide, cyano, oxime, bromo, methoxy and dihydroxy functional groups have all been introduced principally through
3-(Substituted) vinyl cephalosporins
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, (2008/06/13)
New 3-(substituted) vinyl cephalosporin compounds, e.g., 3-(2'-ethoxycarbonylvinyl)-7-phenoxyacetamido-3-cephem-4-carboxylic acid, which are useful as antibiotics, and 3-(substituted) vinyl cephalosporin compounds which are useful as intermediates in preparing antibiotic substances.
