295779-86-1 Usage
Uses
Used in Pharmaceutical Industry:
Ethanone, 1-(3-fluoro-2-methoxyphenyl)(9CI) is used as a reactant for the preparation of coumestan derivatives. These derivatives serve as polyketide synthase 13 inhibitors, which are crucial in the development of treatments against Mycobacterium tuberculosis. Ethanone, 1-(3-fluoro-2-methoxyphenyl)(9CI)'s ability to inhibit this enzyme contributes to its potential as a therapeutic agent in the fight against tuberculosis.
Preparation
Obtained by reaction of 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoro-borate) with 2-methoxyacetophenone in refluxing acetonitrile for 0.5–4 h.
Check Digit Verification of cas no
The CAS Registry Mumber 295779-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,5,7,7 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 295779-86:
(8*2)+(7*9)+(6*5)+(5*7)+(4*7)+(3*9)+(2*8)+(1*6)=221
221 % 10 = 1
So 295779-86-1 is a valid CAS Registry Number.
295779-86-1Relevant academic research and scientific papers
ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Paragraph 0279; 0286; 0287; 0741; 0742; 0743, (2017/06/12)
A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.
Solvent directing immediate fluorination of aromatic ketones using 1- fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
Stavber, Stojan,Jereb, Marjan,Zupan, Marko
, p. 1323 - 1324 (2007/10/03)
Reactions of aryl alkyl ketones with 1-fluoro-4-hydroxy1,4- diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Accufluor(TM) NFTh) in methanol result in selective and almost quantitative formation of the corresponding α-fluoroketones, while in acetonitrile exclusive fluorofunctionalisation of the activated aromatic ring take place.
