29587-08-4Relevant articles and documents
Method for synthesizing isopropyl-beta-D-thiogalactoside (IPTG)
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Paragraph 0017; 0018; 0019, (2018/11/22)
The invention provides a method for synthesizing isopropyl-beta-D-thiogalactoside (IPTG) and belongs to the technical field of organic synthesis. The method comprises the following steps: taking a compound beta-D-galactose pentaacetate as a raw material, and reacting with potassium ethyl xanthate in the presence of a catalyst so as to obtain tetraacetyl galactose ethyl xanthate; reacting with 2-bromopropane under an alkaline condition, so as to obtain the isopropyl-beta-D-thiogalactoside (IPTG). According to the synthetic method, the beta-D-galactose pentaacetate, potassium ethyl xanthate and2-bromopropane are taken as main raw materials, 2-mercaptopropane which is extremely unpleasant in smell, easy to diffuse and high in toxicity used in the original method is replaced, and the harm tothe environment is effectively avoided. The raw materials used in the method disclosed by the invention are readily available, the operating process is simple and convenient, the reaction condition ismild, and the method is safe, controllable and high in yield.
A novel synthesis of trehalose-type thiodisaccharides. An anomalous reaction of potassium methyl- and benzyl-xanthates with halogeno-O-acetyl sugars in acetone.
Akagi,Tejima,Haga,Sakata
, p. 1081 - 1082 (2007/10/05)
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