29618-19-7

Basic information

• Product Name: (S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one
• Synonyms: (S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one;2-amino-3-phenyl-1-(1-piperidinyl)-1-Propanone
• CAS NO: 29618-19-7
• Molecular Formula: C₁₄H₂₀N₂O
• Molecular Weight: 232.3214
• Mol File: 29618-19-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one(29618-19-7)
• EPA Substance Registry System: (S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one(29618-19-7)

Safety Data

• Hazardous Substances Data: 29618-19-7(Hazardous Substances Data)

Usage

General Description

(S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one, also known as (S)-amphetamine, is a chemical compound that belongs to the class of amphetamines. It is a psychoactive drug that acts as a central nervous system stimulant, increasing the release of neurotransmitters such as dopamine and norepinephrine. (S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one is widely used for its effects on mood, energy, and cognitive functions, and it has a high potential for abuse and addiction. (S)-amphetamine is commonly found in prescription medications for attention deficit hyperactivity disorder (ADHD) and narcolepsy, but it is also used illicitly as a recreational drug due to its euphoric and stimulating effects. Its use as a performance-enhancing drug has also been reported in some cases.

Upstream product

• 110-89-4 piperidine 
• 126727-04-6 2-(9-fluorenylmethoxycarbonylamino)-3-phenylpropionic acid 

Relevant articles and documents

Tertiary-butoxycarbonyl (Boc) – A strategic group for N-protection/deprotection in the synthesis of various natural/unnatural N-unprotected aminoacid cyanomethyl esters

A number of cyanomethyl esters of natural/unnatural aminoacids with un-protected amino functionality were synthesized because of their synthetic and medicinal importance. Critical N-Boc deprotection methods in the presence of labile (hydrolytic sensitivity) cyanomethyl functionality were screened thoroughly and it was found that readily available 4M HCl in 1,4-dioxane solution (2–4 equiv); acetonitrile, 0 °C, 2–4 h was a suitable condition. This condition was generalized and successfully applied to a variety of alkyl, alkynyl, aryl, heteroaryl, benzyl, azido, spiro amino acid cyanomethylesters irrespective of the nature of the amine (primary or secondary) and the distance between the amine and ester group to achieve final deprotected amino esters with high yield, and purity compared to other commonly known N-protecting groups (Cbz, Fmoc, Ac, Bn, Bz etc.). It was also demonstrated that N-Boc protected aminoacid cyanomethylesters are stable enough to carry out further functionalization compared to N-unprotected counterparts.