126727-04-6

Basic information

• Product Name: 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID
• Synonyms: N-FMOC-DL-phenylalanine;N-9-Fluorenylmethoxycarbonyl-DL-phenylalanine;(9H-Fluoren-9-yl)MethOxy]Carbonyl DL-Phe-OH
• CAS NO: 126727-04-6
• Molecular Formula: C₂₄H₂₁NO₄
• Molecular Weight: 387.43
• Mol File: 126727-04-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID(126727-04-6)
• EPA Substance Registry System: 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID(126727-04-6)

Safety Data

• Hazardous Substances Data: 126727-04-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID is used as a research compound for its potential therapeutic properties, specifically for the development of new medications aimed at pain relief and the treatment of inflammatory conditions. Its chemical structure allows for exploration in various medicinal applications, making it a promising candidate for further studies and drug design.
Used in Anti-inflammatory and Analgesic Medications:
In the pharmaceutical industry, 2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-3-PHENYL-PROPIONIC ACID is used as a potential active ingredient in the development of anti-inflammatory and analgesic medications. Its properties suggest that it may contribute to the management of pain and inflammation, offering a new avenue for treatment options in these therapeutic areas.

Upstream product

• 909114-66-5 9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate 
• 150-30-1 Phenylalanine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 84889-09-8 (fluorenyl-9-methoxycarbonyl)diphenylalanine 

Relevant articles and documents

Determination of Chemical and Enantiomeric Purity of α-Amino Acids and their Methyl Esters as N-Fluorenylmethoxycarbonyl Derivatives Using Amylose-derived Chiral Stationary Phases

Liquid chromatographic enantiomer separation and simultaneous determination of chemical and enantiomeric purity of α-amino acids and their methyl esters as N-fluorenylmethoxycarbonyl (FMOC) derivatives was performed on three covalently bonded type chiral stationary phases (CSPs) derived from amylose derivatives. The enantiomer separation of α-amino acid esters as N-FMOC derivatives was better than that of the corresponding acids, especially for CSP 1 and 2. Chemical impurities as the corresponding racemic acids present in several commercially available racemic amino acid methyl esters were observed to be 0.49–17.50%. Enantiomeric impurities of several commercially available L-amino acid methyl esters were found to be 0.03–0.58%, whereas chemical impurities as the corresponding racemic acids present in the same analytes were found to be 0.13–13.62%. This developed analytical method will be useful for the determination of chemical and enantiomeric purity of α-amino acids and/or esters as N-FMOC derivatives using amylose-derived CSPs.

MgI2-Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies

The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports. Amazing MgI2: Protecting groups have had a tremendous positive impact on the art of biomolecule synthesis. In a context in which the use of attractive protecting groups is often limited by harsh deprotection conditions and low chemoselective flexibility, MgI2 offers, by the execution of a very simple protocol, a fresh vision with extensive perspectives.

Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional 12C/1H and heavy stable isotope 13C/2H-labeled chelator-amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals. The Royal Society of Chemistry 2013.

A SYNTHETIC CYCLIC DIPEPTIDE AND A PROCESS THEREOF

The disclosure relates to preparation and self-assembly of aromatic cyclic dipeptide into one and two dimensional nano, meso and micro structures. The said structures of cyclic dipeptide can be electrospinned into threads, fabrics, suture, bandage materials. They are also useful in cell culturing, tissue culturing, drug delivery system, as composite materials, as inhibitors of fibrillization and in Biomedical research such as neurological regeneration and organ replacement studies.

Facile and selective deallylations of esters under 'aqueous' free-radical conditions

The conversion of allyl esters into carboxylic acids using radical initiators has been achieved in high yields in aqueous media. Georg Thieme Verlag Stuttgart.

Useful reagents for introduction of Boc and Fmoc protective groups to amines: Boc-DMT and Fmoc-DMT

New amino-protecting reagents, Boc-DMT and Fmoc-DMT, were prepared, and found to be useful for the introduction of Boc and Fmoc groups into amines. Both the reagents can protect various amines including amino acids in good yield in aqueous media. Since the reagents are neither unstable nor irritating, they are practically useful. Georg Thieme Verlag Stuttgart.