2962-63-2Relevant academic research and scientific papers
1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes and Related Derivatives as Ligands for the Neuromodulatory ?3 Receptors: Further Structure-Activity Relationships
Wyrick, Steven D.,Booth, Raymond G.,Myers, Andrew M.,Owens, Constance E.,Bucholtz, Ehren C.,et al.
, p. 3857 - 3864 (2007/10/02)
A series of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes (1-phenyl-3-aminotetralins, PATs) previously was found to stimulate tyrosine hydroxylase activity and dopamine synthesis in rat brain through interaction with a novel ?3 receptor.Speci
Synthesis and Pharmacological Evaluation of 1-Phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as Ligands for a Novel Receptor with ?-like Neuromodulatory Activity
Wyrick, Steven D.,Booth, Raymond G.,Myers, Andrew M.,Owens, Constance E.,Kula, Nora S.,et al.
, p. 2542 - 2551 (2007/10/02)
Certain novel 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes (1-phenyl-3-aminotetralins, PATs) produced stimulation (ca. 30percent above basal levels) of tyrosine hydroxylase (TH) activity at 0.1 μM concentrations in rodent brain tissue. This effect on T
Photoinduced Nucleophilic Addition of Ammonia and Alkylamines to Aryl-Substituted Alkenes in the Presence of p-Dicyanobenzene
Yamashita, Toshiaki,Shiomori, Koichiro,Yasuda, Masahide,Kensuke, Shima
, p. 366 - 374 (2007/10/02)
The photoamination of 1,1-diphenylpropene (1a) with ammonia and some primary alkylamines in the presence of p-dicyanobenzene gave the corresponding N-substituted 2-amino-1,1-diphenylpropane (2a-e) along with the formation of 3-methyl-4,4-diphenylbutanenitrile (3a), 1,1-diphenylpropane (4a), 3,3-diphenylpropene (5), and diphenylmethane (6).In the case of 1,1-diphenylethene (1b), N-substituted 1-amino-2,2-diphenylethane (2f-h), 4,4-diphenylbutanenitrile (3b), and 1,1-diphenylethane (4b) were produced.In photoamination with t-butylamine in acetonitrile, 3a and 3b were mainly formed as a consequence of the incorporation of acetonitrile to 1a and 1b.The photoamination of 1-phenyl-3,4-dihydronaphthalene (1c) with isopropylamine or t-butylamine gave cis- and trans-N-substituted 1-phenyl-2-amino-1,2,3,4-tetrahydronaphthalenes (15 and 16) in a ratio of ca. 8:2.The mechanism of photoamination is discussed in terms of a photochemical electron transfer of 1 to p-dicyanobenzene followed by a nucleophilic addition of the amine to the cation radical of 1.
BENZO- AND INDOLOQUINOLIZIDINE DERIVATIVES XIX. THE SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SOME QUINOLIZIDINE DERIVATIVES, ANALOGUES OF BUTACLAMOL
Laus, G.,Tourwe, D.,Binst, G. Van
, p. 311 - 331 (2007/10/02)
Indenopyridoisoquinoline and benzopyridophenanthridine derivatives were synthesized as the conformationally rigid analogues of butaclamol.For both series, a unique reaction scheme has been worked out in order to obtain the desired trans-cisoid-cis conform
