296229-44-2Relevant academic research and scientific papers
Asymmetric synthesis of β-substituted Baylis-Hillman products via lithium amide conjugate addition
Chernega, Alexander,Davies, Stephen G.,Elend, Dirk. L.,Smethurst, Christian A.P.,Roberts, Paul M.,Smith, Andrew D.,Smyth, G. Darren
, p. 7036 - 7046 (2008/02/05)
A three-step protocol for the asymmetric synthesis of a range of β-substituted Baylis-Hillman products has been developed. This procedure involves the diastereoselective conjugate addition of lithium (R)-N-methyl-N-(α-methylbenzyl)amide to an α,β-unsatura
Asymmetric synthesis of homochiral Baylis-Hillman products employing (R)-N-methyl-N-α-methylbenzyl amide
Davies, Stephen G.,Smethurst, Christian A.P.,Smith, Andrew D.,Smyth, G. Darren
, p. 2437 - 2441 (2007/10/03)
The conjugate addition of (R)-N-methyl-N-α-methylbenzyl amide to tert-butyl cinnamate followed by an asymmetric aldol reaction and subsequent N-oxidation/Cope elimination affords β-substituted homochiral Baylis-Hillman products in good yield. Copyright (C
