296237-49-5

Basic information

• Product Name: 3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one
• Synonyms: 3-Methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one; 6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-
• CAS NO: 296237-49-5
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 285.3377
• Mol File: 296237-49-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 397.4°C at 760 mmHg
• Flash Point: 194.1°C
• Density: 1.28g/cm³
• Vapor Pressure: 1.59E-06mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one(296237-49-5)
• EPA Substance Registry System: 3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one(296237-49-5)

Safety Data

• Hazardous Substances Data: 296237-49-5(Hazardous Substances Data)

Upstream product

• 261961-56-2 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one 
• 296237-48-4 C₁₉H₂₀BrNO₅ 
• 357-70-0 Galantamine 
• 1212320-02-9 6-methoxy-10-methyl-galanthaman-3-ol 
• 934415-11-9 galantamine 
• 122584-14-9 N-formyl-1-bromo-narwedine 
• 261961-51-7 4a,5,9,10,11,12-hexhydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ethylene ketal 
• 252869-10-6 4a,5,9,10,11,12-hexhydro-1-bromo-3-methoxy-11-formyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-propylene ketal 

Downstream Products

• 510-77-0 (-)-narwedine 
• 26601-10-5 (-)4a,5,9,10,11,12-hexhydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one 
• 357-70-0 galanthamine 

Relevant articles and documents

METHOD FOR THE PRODUCTION OF HIGH-PURITY 4A, 5, 9, 10, 11, 12,-HEXAHYDRO-6H-BENZOFURO [3A, 3, 2-EF] [2] BENZAZEPINE, AND THE DERIVATIVES THEREOF

A process for the production of extremely pure galanthamine or extremely pure galanthamine derivatives, whereby a start is made from racemic bromine narwedine, which is debrominated under palladium catalysis. The working-up of the reaction mixture, which is carried out in the presence of oxygen or peroxides, is essential to the process, so that the palladium catalyst is converted into an insoluble form, a form that can be easily separated. The further reaction is carried out by reduction of enantiomerically pure narwedine to form enantiomerically pure galanthamine, whereby it is then alkylated or dealkylated, so that a corresponding substitution on the ring-nitrogen atom is achieved. By further purification, such as recrystallization, residual portions of palladium of below 5 ppm are achieved, so that the direct use as a pharmaceutical raw material is made possible.

Processes for the preparation of derivatives of 4a, 5, 9, 10, 11, 12-hexahydro-6H-benzofuro-[3a, 3, 2-ef][2]benzazepine

The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a, 5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepine.

Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2]benzazepine

The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine.