261961-56-2

Basic information

• Product Name: 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one
• Synonyms: 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one
• CAS NO: 261961-56-2
• Molecular Weight: 378.222
• Mol File: 261961-56-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one(261961-56-2)
• EPA Substance Registry System: 4a,5,9,10,11,12-hexahydro-1-bromo-3-methoxy-11-methyl-6H-12-oxobenzofuro[3a,3,2,-ef][2]-benzazepin-6-one(261961-56-2)

Safety Data

• Hazardous Substances Data: 261961-56-2(Hazardous Substances Data)

Upstream product

• 24958-44-9 2-bromo-4-methoxy-5-hydroxy-N-[2-(4-hydroxyphenyl)-ethyl]-N-methylbenzamide 

Downstream Products

• 357-70-0 galanthamine 
• 296237-49-5 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one 

Relevant articles and documents

Syntheses and Preparations of Narwedine and Related Novel Compounds

The present invention relates to a process for preparing racemic narwedine (which can be can be kinetically resolved) to yield (?)-narwedine and which is the biogenic precursor of (?)-galanthamine) and the use thereof as a starting material for producing (?)-galanthamine. The invention further includes processes for preparing (?)-galanthamine and (?)-galanthamine hydrobromide, as well as related novel compounds.

Preparation of (-)-galantamine hydrobromide

A process for preparing (?)-galantamine hydrobromide.

New achievements in the field of intramolecular phenolic coupling reactions, using hypervalent (III) iodine reagent: Synthesis of galanthamine

Our investigations on the Oxidative possibilities of the hypervalent iodine(III) reagent established that phenyliodine(III)bis(trifluoroacctate (PIFA) can provide one-pot contiguous coupling-cyclization reaction giving a product with narwedine skeleton, when used in a phenolic coupling reaction of p'-bromonorbelladine derivatives. A suitably selected precursor gave up to 60% yield of the coupled product.