296240-35-2

Upstream product

• 832690-29-6 (2S,3R,4R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-4-(4-methoxy-phenoxymethyl)-3-phenyl-tetrahydro-pyran 
• 329684-91-5 (3S,6S)-cis-6-(tert-butyldimethylsilyloxy)-3,6-dihydro-2H-pyran-3-yl acetate 
• 329684-93-7 (3S,6S)-6-(tert-butyldimethylsilyloxy)-3,6-dihydro-2H-pyran-3-ol 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 
• 942514-60-5 C₁₅H₁₂F₆O₃ 
• 942514-59-2 C₁₅H₁₄F₆O₃ 
• 942514-57-0 C₁₇H₁₆F₆O₄ 
• 832690-27-4 (2R,3R,4R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-4-(4-methoxy-phenoxymethyl)-3-phenyl-tetrahydro-pyran 

Downstream Products

• 648928-71-6 (2R,3R,4R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]tetrahydro-3-phenyl-2H-pyran-4-ylmethyl benzenesulfonate 

Relevant academic research and scientific papers

Stereoselective nucleophilic substitution of 6-(tert-butyldimethylsilyloxy)-3,6-dihydro-2H-pyran-3-yl acetate: application to the synthesis of a NK1 receptor antagonist

Reaction of chiral cis- and trans-6-(tert-butyldimethylsilyloxy)-3,6-dihydro-2H-pyran-3-yl acetates with various nucleophiles (allyltrimethylsilane, bistrimethylsilylacetylene, benzyl alcohol, benzyl carbamate etc.) in the presence of a Lewis acid gave th

Synthesis of a potent hNK-1 receptor antagonist via an SN2 reaction of an enantiomerically pure α-alkoxy sulfonate

(Chemical Equation Presented) The concise synthesis of a stereochemically rich hNK-1 receptor antagonist is described. The synthesis is highlighted by an SN2 reaction of an enantiomerically pure α-alkoxy sulfonate (orthogonally protected butane triol), which was prepared by utilizing salen-mediated hydrolytic kinetic resolution technology. A stereocontrolled acetalization was employed to connect two enantiomerically pure fragments with a high degree of diastereoselectivity.