368-63-8

Basic information

• Product Name: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
• Synonyms: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL;1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;3,5-BIS(TRIFLUOROMETHYL)-A-METHYLBENZYL ALCOHOL;ALFA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL;alpha-Methyl-3,5-bis(trifluoromethyl)benzyl alcohol;3,5-Bis(trifluoromethyl)phenylethanol;alpha-Methyl-3,5-Bis(trifluoromethyl)Benzylalcohol99+%;à-Methyl-3,5-bis-(trifluoromethyl)-benzyl alcohol
• CAS NO: 368-63-8
• Molecular Formula: C₁₀H₈F₆O
• Molecular Weight: 258.16
• Product Categories: PHARMACEUTICAL INTERMEDIATES;Aromatic alcohols and diols
• Mol File: 368-63-8.mol
• Article Data: 153

Chemical Properties

• Melting Point: 70-74℃
• Boiling Point: 175.8 °C at 760 mmHg
• Flash Point: 60.1 °C
• Appearance: /
• Density: 1.376 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.99±0.20(Predicted)
• CAS DataBase Reference: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL(368-63-8)
• EPA Substance Registry System: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL(368-63-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 368-63-8(Hazardous Substances Data)

Usage

General Description

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL is a chemical compound that belongs to the class of alcohols. It is a colorless liquid with a molecular formula C10H7F6O and a molecular weight of 274.15 g/mol. 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL is commonly used as a reagent in organic synthesis and as a building block for the production of various pharmaceuticals and agrochemicals. It is known for its strong electron-withdrawing trifluoromethyl groups, which make it a versatile building block for organic synthesis. Additionally, it is important to note that this compound should be handled with caution, as it may cause irritation to the skin, eyes, and respiratory system, and should only be used in a well-ventilated area and with appropriate personal protective equipment.

Upstream product

• 112981-69-8 3,5-bis(trifluoromethyl)phenylmagnesium bromide 
• 75-07-0 acetaldehyde 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 349-59-7 3,5-bis(trifluoromethyl)styrene 
• 925-90-6 ethylmagnesium bromide 
• 68120-60-5 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol 
• 108-05-4 vinyl acetate 
• 534613-13-3 (R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol 
• 22348-32-9 (S)-diphenylprolinol 
• 849674-12-0 (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl-2,2,2-trichloroethanimidoate 
• 1021816-97-6 C₁₄H₁₇FO₂ 
• 225920-05-8 (S)-3,5-bis(trifluoromethyl)-1-phenylethanol 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 225920-05-8 (S)-3,5-bis(trifluoromethyl)-1-phenylethanol 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 
• 534613-13-3 (R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol 
• 160376-84-1 1-[3,5-bis(trifluoromethyl)phenyl]ethyl bromide 
• 892868-64-3 [(3R,4R,5R,6R)-4-[(benzyloxy)methyl]-6-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]-ethoxy}-5-(4-fluorophenyl)tetrahydro-2H-pyran-3-yl]methyl 4-nitrobenzoate 
• 892868-78-9 [(3R,4R,5R,6R)-4-[(benzyloxy)methyl]-6-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-5-(4-fluoro-2-methylphenyl)tetrahydro-2H-pyran-3-yl]methyl 4-nitrobenzoate 
• 643756-80-3 C₂₇H₂₉F₆NO₄ 
• 606137-78-4 1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene 
• 1360454-52-9 (S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl propanoate 
• 1384108-70-6 sodium (S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl sulfate 
• 1384108-58-0 sodium rac-1-[3,5-bis(trifluoromethyl)phenyl]ethyl sulfate 
• 127733-40-8 (S)-α-(3,5-bis(trifluoromethyl)phenyl)ethylamine 

Relevant articles and documents

Mn(i) phosphine-amino-phosphinites: a highly modular class of pincer complexes for enantioselective transfer hydrogenation of aryl-alkyl ketones

A series of Mn(i) catalysts with readily accessible and more π-accepting phosphine-amino-phosphinite (P′(O)N(H)P) pincer ligands have been explored for the asymmetric transfer hydrogenation of aryl-alkyl ketones which led to good to high enantioselectivities (up to 98%) compared to other reported Mn-based catalysts for such reactions. The easy tunability of the chiral backbone and the phosphine moieties makes P′(O)N(H)P an alternative ligand framework to the well-known PNP-type pincers.

Method for refining chiral alcohol

The invention relates to a method for refining chiral alcohol shown as a formula (I). The method comprises the following steps: providing a crude product of the chiral alcohol shown as the formula (I); refining the crude product of chiral alcohol shown in the formula (I) by adopting a refining solvent to prepare a refined product of chiral alcohol shown in the formula (I); wherein the refining solvent is selected from at least one of diethyl ether, n-heptane, methyl tert-butyl ether and isopropyl ether; according to the refining method of the chiral alcohol, on the basis of ensuring the yield of the chiral alcohol, the residual quantity of process impurities can be controlled to be below 0.3%. The refining method is simple, special instruments and equipment are not needed, special operation skills are also not needed, and therefore the refining method is particularly suitable for industrial production and application.

Manganese-catalyzed homogeneous hydrogenation of ketones and conjugate reduction of α,β-unsaturated carboxylic acid derivatives: A chemoselective, robust, and phosphine-free in situ-protocol

We communicate a user-friendly and glove-box-free catalytic protocol for the manganese-catalyzed hydrogenation of ketones and conjugated C[dbnd]C[sbnd]bonds of esters and nitriles. The respective catalyst is readily assembled in situ from the privileged [Mn(CO)5Br] precursor and cheap 2-picolylamine. The catalytic transformations were performed in the presence of t-BuOK whereby the corresponding hydrogenation products were obtained in good to excellent yields. The described system offers a brisk and atom-efficient access to both secondary alcohols and saturated esters avoiding the use of oxygen-sensitive and expensive phosphine-based ligands.