296271-95-9

Basic information

• Product Name: 1-(4-methylphenyl)-5-(3-methoxyphenyl)-1,3-dihydrospiro(1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)-1',3',4,6(2'H,3H,5H)-tetrone
• Synonyms: 1-(4-methylphenyl)-5-(3-methoxyphenyl)-1,3-dihydrospiro(1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)-1',3',4,6(2'H,3H,5H)-tetrone
• CAS NO: 296271-95-9
• Molecular Formula: C28H21NO6
• Molecular Weight: 467.46944
• Mol File: 296271-95-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-methylphenyl)-5-(3-methoxyphenyl)-1,3-dihydrospiro(1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)-1',3',4,6(2'H,3H,5H)-tetrone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)-5-(3-methoxyphenyl)-1,3-dihydrospiro(1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)-1',3',4,6(2'H,3H,5H)-tetrone(296271-95-9)
• EPA Substance Registry System: 1-(4-methylphenyl)-5-(3-methoxyphenyl)-1,3-dihydrospiro(1H-furo[3,4-c]pyrrole-3,2'-[1'H]-indene)-1',3',4,6(2'H,3H,5H)-tetrone(296271-95-9)

Safety Data

• Hazardous Substances Data: 296271-95-9(Hazardous Substances Data)

Upstream product

• 31460-27-2 3-(3-methoxy-phenylcarbamoyl)-acrylic acid 
• 536-90-3 m-Anisidine 
• 3007-23-6 N-(3-methoxyphenyl)maleimide 
• 104-87-0 4-methyl-benzaldehyde 
• 1807-49-4 2-diazo-indan-1,3-dione 
• 606-23-5 1H-indene-1,3(2H)-dione 

Relevant articles and documents

The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation

Adenylate cyclases (ACs), play a critical role in the conversion of adenosine triphosphate (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biological assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10 μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chemical probe to study the physiological function of AC2.