296274-01-6Relevant articles and documents
Sulfonamide Inhibitors of β-Catenin Signaling as Anticancer Agents with Different Output on c-MYC
Di Magno, Laura,Di Pastena, Fiorella,Puxeddu, Michela,La Regina, Giuseppe,Coluccia, Antonio,Ciogli, Alessia,Manetto, Simone,Maroder, Marella,Canettieri, Gianluca,Silvestri, Romano,Nalli, Marianna
, p. 2264 - 2268 (2020)
The Wnt/β-catenin pathway is often found deregulated in cancer. The aberrant accumulation of β-catenin in the cell nucleus results in the development of various malignancies. Specific drugs against this signaling pathway for clinical treatments have not b
Arylation and alkenylation of activated alkyl halides using sulfonamides
Greaney, Michael F.,Johnson, Stuart,Kovács, Ervin
supporting information, p. 3222 - 3224 (2020/03/23)
A variety of quaternary aryl amino acid derivatives can be synthesised using tandem SN2/Smiles rearrangement chemistry involving aryl sulfonamides and α-chloro carbonyl compounds. The reaction harnesses a sulfur dioxide extrusion pathway to construct a C-N and C-Caryl bond under simple conditions with no requirement for organometallics or transition metal catalysts. The reaction is also successful for alkenyl sulfonamides, producing sterically congested quaternary alkene amino acid derivatives.
