296277-06-0

Upstream product

• 2740-83-2 3-(TRIFLUOROMETHYL)BENZYLAMINE 
• 333-20-0 potassium thioacyanate 

Downstream Products

• 1314743-24-2 C₂₁H₁₈ClF₃N₂O₂S 

Relevant academic research and scientific papers

Synthesis, biological evaluation, and metabolic stability of chlorogenic acid derivatives possessing thiazole as potent inhibitors of α-MSH-stimulated melanogenesis

A series of catechol and dioxolane analogs containing thiazole CGA derivatives have been synthesized and evaluated for their inhibitory activity against α-MSH. The inhibitory activity was improved by replacing an α,β-unsaturated carbonyl of previously reported caffeamides with thiazole motif. Surprisingly, compound 7d, one of the derivatives of dioxolane analogs, displayed the most potent inhibitory activity with an IC50 of 0.90 μM. Further studies on metabolic stability and bioactivation potential were also accomplished.

Novel Chlorogenic Acid Derivatives and Anti-Inflammatory and Skin Whitening Composition Comprising the Same

The present invention relates to a novel chlorogenic acid derivative compound having an anti-inflammatory activity and a skin whitening activity, a use of the compound, and a manufacturing method of the compound. The compound of the present invention inhibits an NF- κB activation path, and inhibits an activity of α-melanocyte-stimulating hormone (α-MSH), thereby having the anti-inflammatory activity and the skin whitening activity. The compound of the present invention can be developed as a treating agent of inflammatory diseases and a skin whitening agent.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA

The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.