296279-01-1Relevant academic research and scientific papers
Design, synthesis and in vitro cytotoxicity evaluation of new 3',4'-bis (3,4,5-trisubstituted)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one derivatives as promising anticancer agents
Abolhasani, Hoda,Zarghi, Afshin,Abolhasani, Ahmad,Hamzeh-Mivehroud, Maryam,Bargahi, Nasrin,Notash, Behrouz,Mojarrad, Javid Shahbazi,Dastmalchi, Siavoush
, p. 1149 - 1161 (2015/03/31)
A new series of 3',4'-bis(3,4,5-trimethoxyphenyl)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one derivatives was designed and synthesized. The cytotoxic effects of the synthesized compounds were evaluated on several different human cancer cells. Among them, compound 9e displayed the most potent in vitro antiproliferative activity with IC50 values of 0.07±0.01 μM on T47D cells. Another potent derivative 9h displayed an IC50 value of 0.12±0.07 μM against T47D cells, comparable to that of the positive controls (Colchicine' Cisplatin' Vincristine' Vinblastine' Doxorubicin' Celecoxib). The structure-activity relationships were discussed and both anti-tubulin and COX-2 inhibitory effects were proposed for the developed compounds
Dimerization of conjugated 1-indanones
Leblanc,Dufresne,Dhawan,Ollerenshaw,Littke,Trimble,Tsou
, p. 784 - 790 (2007/10/03)
Conjugated 1-indanones dimerize under basic conditions to provide spirodimers. For example when 2-(E)-carbomethoxymethylene-1-indanone (5) was treated with Cs2CO3 in CH3CN, two spirodimers, 6 and 7, were produced via two m
