29655-68-3

Upstream product

• 2840-26-8 3-amino-4-methoxybenzoic acid 
• 24812-90-6 methyl 3-amino-4-methoxybenzoate 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1428847-49-7 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(methylsulfonamido)benzoyloxy)-acetoxy)ethyl)pyridine 1-oxide 
• 1428848-13-8 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(methylsulfonamido)-benzoylthio)acetoxy)ethyl)pyridine 1-oxide 
• 1428847-51-1 methyl 3-(N-(tert-butoxycarbonyl)-methylsulfonamido)-4-methoxybenzoate 
• 1428848-09-2 methyl 4-methoxy-3-(N-(2-morpholinoethyl)methyl-sulfonamido)benzoate 
• 1428848-08-1 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride 
• 1610860-40-6 methyl 4-methoxy-3-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate 
• 1610860-39-3 methyl 3-(N-(2-bromoethyl)methylsulfonamido)-4-methoxybenzoate 
• 1610860-38-2 methyl 3-(N-(2-hydroxyethyl)methylsulfonamido)-4-methoxybenzoate 
• 1428848-15-0 (S)-4-(2-(2-(3-(N-(tert-butoxycarbonyl)-methylsulfonamido)-4-methoxybenzoylthio)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide 
• 1428855-47-3 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride 
• 1428848-12-7 4-(2-(N-(5-((carboxymethylthio)carbonyl)-2-methoxyphenyl)methylsulfonamido)ethyl)morpholin-4-ium 2,2,2-trifluoroacetate 
• 1428847-65-7 4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoic acid 
• 1428847-56-6 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)-methylsulfonamido)benzoyloxy)acetoxy)ethyl)pyridine 1-oxide hydrochloride 
• 1428847-50-0 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)-phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)-benzoyloxy)acetoxy)ethyl)pyridine 1-oxide 

Relevant academic research and scientific papers

1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.

Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases

The first steps in the selection process of a new anti-inflammatory drug for the inhaled treatment of asthma and chronic obstructive pulmonary disease are herein described. A series of novel ester derivatives of 1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4- yl) ethanol have been synthesized and evaluated for inhibitory activity toward cAMP-specific phosphodiesterase-4 (PDE4). In particular, esters of variously substituted benzoic acids were extensively explored, and structural modification of the alcoholic and benzoic moieties were performed to maximize the inhibitory potency. Several compounds with high activity in cell-free and cell-based assays were obtained. Through the evaluation of opportune in vitro ADME properties, a potential candidate suitable for inhaled administration in respiratory diseases was identified and tested in an in vivo model of pulmonary inflammation, proving its efficacy.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline derivatives. II. Their renal vasodilation activity and structure-activity relationship

A series of 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline derivatives showed potent DA1 agonistic activities. We investigated the structure-activity relationship of the racemic compounds of this series. 4- (3,4-Dihydroxyphenyl)-7-metha