29665-57-4

Upstream product

• 693-67-4 bromoundecane 
• 1296885-08-9 1-benzyloxy-3-(dodec-1-enyl)benzene 
• 60669-22-9 n-undecyltriphenylphosphonium bromide 
• 603-35-0 triphenylphosphine 
• 15890-72-9 laurylmagnesium bromide 

Downstream Products

• 1296885-06-7 m-dodecylbenzenesulfonyl chloride 
• 1296884-96-2 3-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide 
• 29688-03-7 S-3-dodecylphenyl dimethylcarbamothioate 
• 1296885-09-0 O-3-dodecylphenyl dimethylcarbamothioate 
• 30761-86-5 4-Dodecyl-2-hydroxy-benzoesaeure, '4-Dodecyl-salicylsaeure' 

Relevant academic research and scientific papers

Development of sulfonamide AKT PH domain inhibitors

Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations. To examine the effects of structural modification, a set of sulfonamides related to the lead compound was designed, synthesized, and tested for binding to the expressed PH domain of AKT using a surface plasmon resonance-based competitive binding assay. Cellular activity was determined by means of an assay for pAKT production and a cell killing assay using BxPC-3 cells. The most active compounds in the set are lipophilic and possess an aliphatic chain of the proper length. Results were interpreted with the aid of computational modeling. This paper represents the first structure-activity relationship (SAR) study of a large family of AKT PH domain inhibitors. Information obtained will be used in the design of the next generation of inhibitors of AKT PH domain function.

Synthesis and antinematodal activity of 3-n-alkylphenols

Several 3-alkylphenols including 3-undecylphenol, which was isolated from a Sumatran rainforest plant, were synthesized to investigate their antinematodal activity against the phytopathogenic nematodes, Bursapherencus xylophilus. A three-step synthesis involving the treatment of 2-cyclohexen-1-one with the Grignard reagent, oxidation of the resulting 1-alkyl-2-cyclohexen-1-ol and subsequent aromatization of 3-alkyl-2-cyclohexen-1-one successfully afforded such phenols. Among the 3-alkylphenols, 3-nonylphenol showed the highest activity, while 3-decylphenol and 3-undecylphenol also showed high activity.