296759-12-1

Upstream product

• 496816-92-3 1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid 
• 622-80-0 N-propylaniline 
• 105-53-3 diethyl malonate 
• 300805-42-9 C₂₀H₁₉N₃O₄ 
• 148237-78-9 ethyl ester of 1-propyl-2-oxo-4-hydroxyquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

4-Hydroxy-2-quinolones. 149*. Synthesis, chemical transformations, and biological properties of β-N-acylhydrazides of 1-R-4-hydroxy-2-oxo-1,2- dihydro-quinoline-4-carboxylic acids

Two methods of preparation have been proposed and the synthesis has been effected of a large series of β-N-acylhydrazides of 1-R-4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids. The possibility of using various condensing agents for converting them into the corresponding 1,3,4-oxa-diazoloquinolines has been studied. Results are given of an investigation of the antitubercular activity of the synthesized compounds.

METHOD FOR SCREENING CYSTEINE PROTEASE INHIBITOR

A method for screening a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion, which comprises treating a cysteine protease with a test compound in the presence of the polyvalent metal ion, and a pharmaceutical composition for treating apoptosis-associated diseases, which contains as the active ingredient a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion.

COMPOSITIONS FOR PREVENTING AND TREATING TYPE I ALLERGY

A method for screening a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion, which comprises treating a cysteine protease with a test compound in the presence of the polyvalent metal ion, and a pharmaceutical composition for treating apoptosis-associated diseases, which contains as the active ingredient a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion.

4-Hydroxy-2-quinolones. 42. Synthesis and biological activity of 1-R-2-oxo-3-(2H-1,2,4-benzothiadiazine-1,1-dioxid-3-yl)-4-hydroxyquinolines

A preparative method for the synthesis of 1-R-2-oxo-3-(2H-1,2,4-benzothiadiazine-l,l-dioxid-3-yl)-4-hydroxyquinolines has been developed. The diuretic and antitubercular activity of the obtained compounds have been studied.