296766-71-7

Upstream product

• 79893-89-3 N-benzoyl-L-threonine methyl ester 

Downstream Products

• 296766-50-2 [(2S,4R,5R)-N-2-(2,2-dimethoxyethyl)-4-methyl-1,3-dioxan-5-yl]benzamide 
• 296766-60-4 N,N'-methylenebis[(2S,4R,5R)/(2S,4S,5S)-4-methyl-1,3-dioxan-2,5-diyl]bisbenzamide 

Relevant academic research and scientific papers

Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes

A new class of 2,5-disubstituted-dioxacycloalkanes were designed and synthesized via stereoselective synthetic method as cancer chemoprevention agents. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Some of these compounds exhibited comparable or better anti-inflammatory activities than that of aspirin suggesting that they can be further developed as potential anti-inflammatory drug lead compounds. In addition, treatment of these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds.

Stereoselective transacetalization of 1,1,3,3-tetramethoxypropane and N- benzoylaminodiols

The transacetalization of 1,1,3,3-tetramethoxypropane and an N- benzoylaminodiol provided stereoselectively the corresponding 2,5- disubstituted-1,3-dioxanes. The stereochemistry of the rings formed in the transacetalization depended on the structure of the amino diol, and the ratio of the products depended on the reaction conditions, as expected. This kind of stereoselective transacetalization not only gives a series of useful building blocks but also generates interesting 1,3-dioxanes which target protein kinase C.