296774-61-3

Upstream product

• 501-53-1 benzyl chloroformate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100-51-6 benzyl alcohol 
• 296774-53-3 4-(3-tert-butoxycarbonylamino-3-methoxycarbonyl-propyl)-benzoic acid 
• 296774-52-2 Boc-hTyrOMe 
• 296774-51-1 L-homotyrosine methyl ester 
• 221243-01-2 (S)-homotyrosine 
• 881205-32-9 L-N^α-(tert-butoxycarbonyl)-4-nitro-homophenylalanine 
• 705919-70-6 L-4-nitro-homophenylalanine 
• 943-73-7 D-homophenylalanine 
• 296774-60-2 4-(4-benzyloxycarbonylamino-phenyl)-2-tert-butoxycarbonylamino-butyric acid methyl ester 

Relevant academic research and scientific papers

New proctolin analogues modified in position 2 or 3 of the peptide chain and their myotropic effects in insects

New analogues of insect neuromodulator proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) modified in position 2 and 3 of the peptide chain by natural or non-natural amino acid residues were synthesized. For modification of proctolin at position 2 a series of novel L-h

Total synthesis and antifungal evaluation of cyclic aminohexapeptides

The need for new therapies to treat systemic fungal infections continues to rise. Naturally occurring hexapeptide echinocandin B (1) has shown potent antifungal activity via its inhibition of the synthesis of β-1,3 glucan, a key fungal cell wall component. Although this series of agents has been limited thus far based on their physicochemical characteristics, we have found that the synthesis of analogues bearing an aminoproline residue in the 'northwest' position imparts greatly improved water solubility (>5 mg/mL). The synthesis and structure-activity relationships (SAR) based on whole cell and upon in vivo activity of the series of compounds are reported. Copyright (C) 2000 Elsevier Science Ltd.