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Upstream product

• 529-20-4 2-methylphenyl aldehyde 
• 55379-01-6 3-(2-methylphenyl)-1,2-benzisothiazole 1,1-dioxide 
• 932-31-0 ortho-tolylmagnesium bromide 
• 81-07-2 saccharin 
• 5669-05-6 1,2-benzoisothiazole 1,1-dioxide 
• 16419-60-6 2-Methylphenylboronic acid 

Relevant academic research and scientific papers

Ni(II)/tBu-SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines

An efficient Ni(ClO4)2·6H2O/SMI-PHOX catalyzed enantioselective addition of arylboronic acids to cyclic N-sulfonyl aldimines is envisioned to afford excellent enantioselectivities (up to 99% ee) in high yields (up to 98%). This protocol offers new opportunities for the synthesis of chiral benzosultams containing a stereogenic tertiary carbon center. The highlights of this method include mild reaction conditions, the use of cheap metal catalyst and a wide substrate scope.

Pd/Zn(OTf)2 Co-Catalyzed Asymmetric Hydrogenation of Imines under Normal Pressure of Hydrogen

An efficient method for the asymmetric hydrogenation of cyclic and acyclic N-sulfonylimines co-catalyzed by Pd/Zn(OTf)2 using hydrogen gas under ambient pressure was developed. The methodology offers an easy access to generate chiral sulfonylam

Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Br?nsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enan

Method for synthesizing chiral sulfanilamides through asymmetric intramolecular reduction and amination under catalysis of palladium

The invention provides a method for synthesizing chiral sulfanilamides through asymmetric intramolecular reduction and amination under catalysis of palladium. A catalysis system used in the method is a chiral diphosphine complexe. Corresponding chiral sulfanilamides are obtained through reduction and amination of a simple and easily available ketoamine substrate, and enantiomeric excess can reach 99%. The method is simple to operate, practical and feasible; raw materials are simple and easily available; the catalyst is commercially available; and reaction conditions are mild. Moreover, high enantioselectivity, good yield and environment friendliness are realized in synthesis of chiral sulfanilamides through asymmetric reduction and amination.

An N-heterocyclic carbene iridium catalyst with metal-centered chirality for enantioselective transfer hydrogenation of imines

A cyclometalating N-heterocyclic carbene iridium complex featuring metal-centered chirality was designed and used for the asymmetric transfer hydrogenation (ATH) of imines. Four strongly σ-donating carbon-based substituents (2 carbenes and 2 phenyl moieti

Method for synthesizing chiral amine through palladium catalyzed asymmetric hydrogenolysis of racemic oxazirine

A catalysis system used in a method for synthesizing chiral amine through palladium catalyzed asymmetric hydrogenolysis of racemic oxazirine is a chiral diphosphine complex of palladium. The racemic substituted oxazirine is hydrogenolyzed to obtain corresponding chiral sulfonamide, and the enantiomeric excess can reach 99%. The method has the advantages of simple, practical and easy operation, commercially available catalyst and mild reaction conditions. The method for synthesizing the chiral sulfonamide through asymmetric hydrogenolysis also has the advantages of high antipodal selectivity, good yield, environmentally-friendly and atomically-economic reaction, and environmental protection.

Formal palladium-catalyzed asymmetric hydrogenolysis of racemic N -sulfonyloxaziridines

Highly enantioselective palladium-catalyzed formal hydrogenolysis of racemic N-sulfonyloxaziridines has been realized, providing a novel access to sultams with up to 99% ee. Preliminary mechanistic insights revealed that the reaction proceeded through a N-O bond cleavage, dehydration, and the sequential asymmetric hydrogenation.

Highly enantioselective synthesis of sultams via Pd-catalyzed hydrogenation

(Chemical Equation Presented) Using pd(cf3co2) 2/(S,S)-f-Binaphane as the catalyst, an efficient enantioselective synthesis of sultams was developed via asymmetric hydrogenation of the corresponding cyclic imines with high