29683-84-9

Basic information

• Product Name: THIOPHENE-2-CARBOXALDOXIME
• Synonyms: 2-THIOPHENECARBALDEHYDE OXIME;THIOPHENE-2-CARBOXALDOXIME;thiophene-2-carbaldehyde oxime;2-Thiophenecarboxaldehyde,oxime(6CI,7CI,8CI,9CI);thiophene-2-aldoxime;Thiophene-2-carboxaldoxime, 98+%;2-Hydroxyiminomethylthiophene;2-thiophenecarboxaldehyde, oxime
• CAS NO: 29683-84-9
• Molecular Formula: C₅H₅NOS
• Molecular Weight: 127.16
• EINECS: 249-778-5
• Product Categories: OXIME
• Mol File: 29683-84-9.mol
• Article Data: 61

Chemical Properties

• Melting Point: 132-136°C
• Boiling Point: 212.8 °C at 760 mmHg
• Flash Point: 82.5 °C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.101mmHg at 25°C
• Refractive Index: 1.606
• BRN: 108676
• CAS DataBase Reference: THIOPHENE-2-CARBOXALDOXIME(CAS DataBase Reference)
• NIST Chemistry Reference: THIOPHENE-2-CARBOXALDOXIME(29683-84-9)
• EPA Substance Registry System: THIOPHENE-2-CARBOXALDOXIME(29683-84-9)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• HazardClass: IRRITANT
• Hazardous Substances Data: 29683-84-9(Hazardous Substances Data)

Usage

General Description

Thiophene-2-carboxaldoxime is a chemical compound with the molecular formula C5H5NOS and a molecular weight of 127.17 g/mol. It is a derivative of thiophene, which is a heterocyclic compound containing a five-membered ring with four carbon atoms and one sulfur atom. Thiophene-2-carboxaldoxime has potential applications in the field of organic synthesis and pharmaceuticals due to its ability to undergo various chemical reactions and form diverse molecular structures. It is commonly used as a building block in the synthesis of complex organic molecules and has shown potential as a precursor in the development of new drugs. Additionally, thiophene-2-carboxaldoxime is known for its ability to chelate metal ions and exhibit coordination chemistry, making it useful in the development of new materials and catalysts. Overall, this compound has promising potential in various fields of chemical research and development.

InChI:InChI=1/C5H5NOS/c7-6-4-5-2-1-3-8-5/h1-4,7H/b6-4+

Upstream product

• 554-14-3 2-Methylthiophene 
• 27757-85-3 2-Aminomethylthiophene 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 98-03-3 thiophene-2-carbaldehyde 
• 1003-31-2 thiophene-2-carbonitrile 
• 5813-89-8 2-thiophenylcarboxamide 
• 1173119-69-1 5-benzenesulfonyl-3-(thiohen-2-yl)-4,5-dihydroisoxazole 
• 67-68-5 dimethyl sulfoxide 
• 10354-43-5 thiophene-2-carboxylic acid benzylamide 
• 21985-10-4 5-phenyl-3-(thiophen-2-yl)isoxazole 
• 527-72-0 2-thiophenylcarboxylic acid 
• 34243-33-9 2-thiophen-2-yl-quinoline 

Relevant articles and documents

Isoxazole derivatives as new nitric oxide elicitors in plants

Several 3,5-disubstituted isoxazoles were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides, generated in situ from the corresponding hydroxyimidoyl chlorides, with non-symmetrical activated alkyn

AN IMPROVED PROCESS FOR PREPARATION OF PURE ALDOXIME

The present invention relates to an improved process for preparing aldoximes of formula (I) with high purity and high yield. The improved process for preparing aldoxime is fast, simple, highly efficient, and reproducible. The improved process for the preparation of aldoxime, which is synthesized in the higher yield under oximation reaction of aldehyde with hydroxylamine hydrochloride merely in aqueous medium using of in situ heat generation.

1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors

Two series of saccharin/isoxazole and saccharin/isoxazoline hybrids were synthesized by 1,3-dipolar cycloaddition. The new compounds showed to be endowed with potent and selective inhibitory activity against the cancer-related human carbonic anhydrase (hCA) IX and XII isoforms in the nanomolar range, while no affinity was encountered for off-targets, such as hCA I and II. Successive enantioseparation on a milligram scale of the most representative compounds led to the discovery that (S)-isomers were more potent than their corresponding (R)-enantiomers. Lastly, molecular modeling studies were conducted to define those structural requirements that were responsible for the discrimination among selected human isoforms of carbonic anhydrases. Two nanomolar hCA IX and XII inhibitors were also screened for their selective toxicity against non tumoral primary cells (fibroblasts) and against a breast adenocarcinoma cell line (MCF7) in hypoxic environment. The efficacious combination of these compounds with doxorubicin on MCF7 cells was demonstrated after 72 h of treatment.