297131-89-6

Upstream product

• 297131-88-5 5-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-74-9 (3R,4S,5R)-5-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-73-8 (E)-(5S,6R)-6-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hept-3-enoic acid methyl ester 
• 297131-87-4 (2R,3R)-3-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyraldehyde 
• 14642-79-6 benzyloxy-trimethylsilane 
• 297131-75-0 (3R,4R,5R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester 

Downstream Products

• 297131-76-1 (E)-(4S,5R,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-5,7,7-trimethyl-oct-2-enedioic acid diethyl ester 
• 351331-56-1 (3S,5R,6R,7S,8S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid isopropyl ester 
• 351331-55-0 (3S,5R,6R,7S,8S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid ethyl ester 
• 351331-49-2 (3R,4R,5S,6S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-2,2,4,6-tetramethyl-octanoic acid ethyl ester 
• 351331-52-7 (3R,4R,5S,6S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-non-8-enoic acid ethyl ester 
• 351331-57-2 (3S,5R,6S,7S,8S)-7-Benzyloxy-3,5-dihydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid isopropyl ester 
• 351331-53-8 (3R,4R,5S,6S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4,6-tetramethyl-non-8-enal 
• 297131-81-8 (12Z,16E)-(3S,5R,6R,7S,8S,15S)-15-Acetoxy-7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dienoic acid isopropyl ester 
• 297131-79-4 Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-benzyloxy-11,13-bis-(tert-butyl-dimethyl-silanyloxy)-8,10,12,12-tetramethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-tridec-3-enyl ester 
• 297131-84-1 (12Z,16E)-(3S,6R,7S,8S,15S)-15-Acetoxy-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic acid isopropyl ester 
• 297131-83-0 (12Z,16E)-(3S,5R,6S,7S,8S,15S)-15-Acetoxy-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dienoic acid isopropyl ester 
• 297131-85-2 (12Z,16E)-(3S,6R,7S,8S,15S)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-15-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic acid 
• 297131-86-3 (Z)-(4S,7R,8S,9S,16S)-8-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-ene-2,6-dione 
• 297131-80-7 Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-benzyloxy-11-(tert-butyl-dimethyl-silanyloxy)-13-hydroxy-8,10,12,12-tetramethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-tridec-3-enyl ester 

Relevant academic research and scientific papers

Methodology based on chiral silanes in the synthesis of polypropionate-derived natural products - Total synthesis of epothilone A

Epothilones A and B (1 and 2) are natural products with potent antitumor activity. These compounds have a Taxol-like mechanism of action against tumor cells. A total synthesis of epothilone A (1) is reported, which is based on the synthesis and union of t

Total synthesis of epothilone A.

[reaction: see text]Epothilones A (1) and B (2) are potent antitumor natural products with a Taxol-like mechanism of action. A total synthesis of epothilone A (1) is reported, which utilized chiral silane-based bond construction methodology to introduce t