297131-82-9

Upstream product

• 297131-81-8 (12Z,16E)-(3S,5R,6R,7S,8S,15S)-15-Acetoxy-7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dienoic acid isopropyl ester 
• 14642-79-6 benzyloxy-trimethylsilane 
• 186692-81-9 (1E,3S,5Z)-2-methyl-6-iodo-1-(2-methyl-1,3-thiazol-4-yl)-1,5-hexadien-3-ol 
• 186692-68-2 (1E,3S,5Z)-2-methyl-6-iodo-1-(2-methyl-1,3-thiazol-4-yl)-1,5-hexadien-3-yl acetate 
• 297131-76-1 (E)-(4S,5R,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-5,7,7-trimethyl-oct-2-enedioic acid diethyl ester 
• 297131-73-8 (E)-(5S,6R)-6-Benzyloxy-7-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hept-3-enoic acid methyl ester 
• 297131-75-0 (3R,4R,5R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-2,2,4-trimethyl-hexanoic acid ethyl ester 
• 297131-78-3 (3S,4S,5R,6R)-4-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-3,5,7,7-tetramethyl-octanal 
• 297131-89-6 (3R,4R,5R)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2,2,4-trimethyl-6-oxo-hexanoic acid ethyl ester 
• 297131-87-4 (2R,3R)-3-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyraldehyde 
• 267877-87-2 (E)-(S)-2-Methyl-1-(2-methyl-thiazol-4-yl)-penta-1,4-dien-3-ol 
• 188730-08-7 (3S,4E)-3-{[tert-butyl(dimethyl)silyl]oxy}-4-methyl-5-(2-methyl-1,3-thiazol-4-yl)pent-4-en-1-al 
• 184246-38-6 (E)-2-methyl-3-(2-methylthiazol-4-yl)acrylaldehyde 
• 188899-14-1 (3S,4E)-3-(tert-butyldimethylsilyloxy)-4-methyl-5-(2-methyl-1,3-thiazol-4-yl)pent-4-en-1-ol 

Downstream Products

• 152044-53-6 epithilone A 
• 186692-73-9 desoxyepothilone A 
• 297131-86-3 (Z)-(4S,7R,8S,9S,16S)-8-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-ene-2,6-dione 
• 297131-85-2 (12Z,16E)-(3S,6R,7S,8S,15S)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-15-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic acid 
• 297131-84-1 (12Z,16E)-(3S,6R,7S,8S,15S)-15-Acetoxy-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic acid isopropyl ester 
• 297131-83-0 (12Z,16E)-(3S,5R,6S,7S,8S,15S)-15-Acetoxy-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dienoic acid isopropyl ester 

Relevant academic research and scientific papers

Methodology based on chiral silanes in the synthesis of polypropionate-derived natural products - Total synthesis of epothilone A

Epothilones A and B (1 and 2) are natural products with potent antitumor activity. These compounds have a Taxol-like mechanism of action against tumor cells. A total synthesis of epothilone A (1) is reported, which is based on the synthesis and union of t