297179-20-5

Basic information

• Product Name: 2,9-Phenanthrenediol, 6,7,8,8a,9,10-hexahydro-4b-(hydroxymethyl)-8,8-dimethyl-1-(1-methylethyl)-, (4bR,8aS,9R)-
• Synonyms: 2,9-Phenanthrenediol, 6,7,8,8a,9,10-hexahydro-4b-(hydroxymethyl)-8,8-dimethyl-1-(1-methylethyl)-, (4bR,8aS,9R)-
• CAS NO: 297179-20-5
• Molecular Formula: C20H30 O3
• Molecular Weight: 0
• Mol File: 297179-20-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,9-Phenanthrenediol, 6,7,8,8a,9,10-hexahydro-4b-(hydroxymethyl)-8,8-dimethyl-1-(1-methylethyl)-, (4bR,8aS,9R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,9-Phenanthrenediol, 6,7,8,8a,9,10-hexahydro-4b-(hydroxymethyl)-8,8-dimethyl-1-(1-methylethyl)-, (4bR,8aS,9R)-(297179-20-5)
• EPA Substance Registry System: 2,9-Phenanthrenediol, 6,7,8,8a,9,10-hexahydro-4b-(hydroxymethyl)-8,8-dimethyl-1-(1-methylethyl)-, (4bR,8aS,9R)-(297179-20-5)

Safety Data

• Hazardous Substances Data: 297179-20-5(Hazardous Substances Data)

Usage

Molecular weight

324.44 g/mol

Structure

Phenanthrene derivative with multiple hydroxyl and methyl groups

Chiral molecule

Stereochemistry described by (4bR,8aS,9R)configuration

Applications

Potential use in medicinal and pharmaceutical research, building block or precursor for synthesis of other organic compounds

Handling

Requires careful handling and precise analysis in research and industrial applications.

Upstream product

• 297179-24-9 13-methoxytotara-8,11,13-trien-6-one 
• 54146-06-4 7α-acetoxy-13-methoxytotara-8,11,13-triene 
• 15423-38-8 13-methoxytotara-6,8,11,13-tetraene 

Relevant articles and documents

The synthesis and antibacterial activity of totarol derivatives. Part 3: modification of ring-B

Ring-B derivatization of totarol (1) afforded the series of compounds 2-22 which were screened in vitro against: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. Several of the derivatives retained much of the antibacterial activity of totatol against the first three of these organisms (all Gram-positive), but none was more active. The Gram-negative Klebsiella was resistant to all compounds examined. Totarol (1) was shown to uncouple oxidative phosphorylation in isolated mitochondria at 50 μM. Copyright (C) 2000 Elsevier Science Ltd.