15423-38-8

Basic information

• Product Name: Phenanthrene, 1,2,3,4,4a,10a-hexahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-
• Synonyms: Phenanthrene, 1,2,3,4,4a,10a-hexahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-
• CAS NO: 15423-38-8
• Molecular Formula: C21H30O
• Molecular Weight: 298.46
• Mol File: 15423-38-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Phenanthrene, 1,2,3,4,4a,10a-hexahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenanthrene, 1,2,3,4,4a,10a-hexahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-(15423-38-8)
• EPA Substance Registry System: Phenanthrene, 1,2,3,4,4a,10a-hexahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-, (4aS,10aS)-(15423-38-8)

Safety Data

• Hazardous Substances Data: 15423-38-8(Hazardous Substances Data)

Upstream product

• 54146-06-4 7α-acetoxy-13-methoxytotara-8,11,13-triene 

Downstream Products

• 297179-20-5 6β,13,20-trihydroxytotara-8,11,13-triene 
• 297179-13-6 totara-8,11,13-triene-6β,13-diol 
• 297179-15-8 6-oxototara-8,11,13-trien-13-ol 
• 297179-24-9 13-methoxytotara-8,11,13-trien-6-one 
• 297179-19-2 13,20-dihydroxytotara-6,8,11,13-tetraene 

Relevant articles and documents

The synthesis and antibacterial activity of totarol derivatives. Part 3: modification of ring-B

Ring-B derivatization of totarol (1) afforded the series of compounds 2-22 which were screened in vitro against: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. Several of the derivatives retained much of the antibacterial activity of totatol against the first three of these organisms (all Gram-positive), but none was more active. The Gram-negative Klebsiella was resistant to all compounds examined. Totarol (1) was shown to uncouple oxidative phosphorylation in isolated mitochondria at 50 μM. Copyright (C) 2000 Elsevier Science Ltd.