297183-18-7

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 4931-66-2 methyl 5-oxopyrrolidine-2-carboxylate 

Downstream Products

• 60693-37-0 1-(4-fluorophenyl)pyrrolidine-2,5-dione 
• 757248-56-9 1-(4-fluorophenyl)-4-[1,2,3-triazol-4⁽⁵⁾-ylcarbonyl]pyrrolidin-2-one 
• 757248-57-0 1-(4-fluorophenyl)-5-(2-methyl-2H-1,2,3-triazol-4-ylcarbonyl)pyrrolidin-2-one 
• 757248-58-1 1-(4-fluoro-phenyl)-5-(3-methyl-3H-[1,2,3]triazole-4-carbonyl)-pyrrolidin-2-one 
• 757248-81-0 1-(4-fluorophenyl)-5-(tetrazol-5-ylacetyl)pyrrolidin-2-one 
• 757248-79-6 5-cyanoacetyl-1-(4-fluorophenyl)pyrrolidin-2-one 

Relevant academic research and scientific papers

Studies on pyrrolidinones. On the application of copper-catalyzed arylation of methyl pyroglutamate to obtain a new benzo[de]quinoline scaffold

Optimized conditions for copper-catalyzed N-arylation of methyl pyroglutamate are described. These studies permitted the synthesis of methyl N-naphthylpyroglutamate, which was then cyclized to a ketone. The known dehydration of amidoketones by PPA was extended to this new scaffold to lead to a novel condensed benzo[de]quinoline with potential antioxidative activity.

Phenylcarboxylic acid derivatives having hetero ring

Phenylcarboxylic acid derivatives having a hetero ring in the substituent of the formula: STR1 wherein R1 is halogen, alkyl, cycloalkyl, hydroxy, alkoxy, phenoxy which has a substituent selected from halogen and alkyl, carboxyl, alkylsulfonyloxy, phenylsulfonyloxy optionally substituted by halogen, alkylsulfonyloxyalkoxy, amino, alkanoylamino, benzoylamino, alkenyloxy, phenylalkoxyalkoxy, hydroxyalkoxy, phenylalkoxy having optionally 1 to 3 substituents selected from halogen, alkyl and alkoxy, halogenoalkyl, cycloalkyloxy optionally substituted by hydroxy, alkoxy substituted by cycloalkyl having optionally hydroxy substituent, imidazolylalkyl or imidazolylalkoxy; k is 0 or 1 to 3; or (R1)k is alkylenedioxy; A is alkylene or alkylenoxy; l is 0 or 1; B is methylene or carbonyl; m is 0 or 1; D is alkylene; E is alkylene or alkenylene; n is 0 or 1; and R2 is hydrogen or alkyl, or a salt thereof, which have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of arteriosclerosis, prophylactic and treating agent of obesity, antidiabetics.