29723-57-7

Upstream product

• 10330-18-4 S-Ethyl-S-phenyl-N-p-tolylsulfonyl-sulfilimin 
• 622-20-8 1,2-bis(phenylthio)ethane 
• 127-65-1 chloroamine-T 
• 123966-28-9 C₂₈H₂₈N₂O₄S₄ 
• 56692-05-8 S-(2-Bromethyl)-S-p-tolyl-N-tosylsulfilimin 
• 56692-06-9 S-ethenyl-S-phenyl-N-(toluene-4-sulfonyl)sulfilimine 
• 4837-01-8 1-bromo-2-phenylthioethane 
• 56692-08-1 C₂₂H₂₃NO₂S₃ 
• 56692-07-0 S-<2-(Phenylthio)aethyl>-S-phenyl-N-p-tosylsulfilimin 

Downstream Products

• 73463-46-4 N-Phenylsulfonyl-N'-p-tosylsulfinamidin 

Relevant academic research and scientific papers

Palladium-catalyzed redox cascade for direct β-arylation of ketones

Herein we report a full article about the detailed design and development of two palladium-catalyzed redox cascade methods that enable direct β-arylation of ketones. Palladium-catalyzed ketone dehydrogenation, aryl-X bond activation and conjugate addition were merged into a redox-neutral catalytic cycle. Non-metal-based aryl electrophiles were used as both the oxidant and the aryl source. The β-arylation with aryl iodides was achieved site-selectively with Pd(TFA)2/P(i-Pr)3 as the precatalyst and AgTFA as the iodide scavenger. Both cyclic and linear ketones can react to give β-aryl ketones with excellent functional group tolerance. The β-arylation with diaryliodonium salts was realized without stoichiometric heavy metal additives, and proved to be redox-neutral. A wider substrate scope regarding aryl groups and ketones was obtained for the arylation with diaryliodonium salts, and the possible involvement of palladium nanoparticles as the active catalyst was examined and discussed.

Palladium-catalyzed direct β-arylation of ketones with diaryliodonium salts: A stoichiometric heavy metal-free and user-friendly approach

We herein report a new protocol for the Pd-catalyzed β-arylation of ketones without stoichiometric heavy metals. Widely accessible diaryliodonium salts are used as both the oxidant and aryl source. This tandem redox catalysis merges ketone dehydrogenation and conjugate addition without an additional oxidant or reductant. This transformation features the use of a unique bis-N-tosylsulfilimine ligand and the combination of potassium trifluoroacetate/trifluoroacetic acid to maintain an appropriate acidity of the reaction medium. The reaction tolerates both air and moisture, and shows a broad substrate scope. Kinetics studies, along with filtration and poisoning tests, support the involvement of palladium nanoparticles in the catalysis.