2975-80-6

Usage

Uses

Used in Pharmaceutical Industry:
10,11-dihydro-5H-Dibenzo[a,d]cycloheptene-5-Methanol is used as a pharmaceutical compound for its potential role in drug development. Its unique structure and functional groups make it a promising candidate for the creation of new medications, particularly in the areas of organic synthesis and medicinal chemistry where its properties can be harnessed to address specific therapeutic needs.
Used in Organic Synthesis:
In the field of organic synthesis, 10,11-dihydro-5H-Dibenzo[a,d]cycloheptene-5-Methanol serves as a key intermediate or building block in the synthesis of more complex organic molecules. Its specific structure allows it to participate in various chemical reactions, facilitating the creation of new compounds with desired properties.
Used in Medicinal Chemistry:
10,11-dihydro-5H-Dibenzo[a,d]cycloheptene-5-Methanol is utilized in medicinal chemistry for the design and optimization of bioactive molecules. Its unique structural features can be leveraged to enhance the potency, selectivity, and pharmacokinetic properties of drug candidates, contributing to the advancement of novel therapeutic agents.

Upstream product

• 16036-72-9 methyl 10,11-dihydro-5H-dibenzocycloheptene-5-carboxylate 
• 67-56-1 methanol 
• 6141-55-5 5-diazo-10,11-dihydro-5H-dibenzo[a,d]cycloheptene 
• 5018-91-7 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxylic acid 
• 24391-61-5 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxaldehyde 
• 93877-28-2 Dibenzocycloheptadien-carbonsaeure-(5)-ethylester 
• 1210-35-1 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one 

Downstream Products

• 597569-75-0 C₂₇H₂₈N₂O₅S 
• 597569-76-1 C₂₇H₂₈N₂O₅S 
• 597569-72-7 C₂₆H₂₆N₂O₅S 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands.

The major excitatory neurotransmitter in the central nervous system, (S)-glutamic acid , activates both ionotropic and metabotropic excitatory amino acid receptors. Its importance in connection to neurological and psychiatric disorders has directed great

Protease inhibitors: Synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties

Novel matrix metalloproteinase (MMP)/bacterial collagenase inhibitors are reported, considering the sulfonylated amino acid hydroxamates as lead molecules. A series of compounds was prepared by reaction of arylsulfonyl isocyanates with N-(5H-dibenzo[a,d]cyclohepten-5-yl)- and N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl) methyl glycocolate, respectively, followed by the conversion of the COOMe to the carboxylate/hydroxamate moieties. The corresponding derivatives with methylene and ethylene spacers between the polycyclic moiety and the amino acid functionality were also obtained by related synthetic strategies. These new compounds were assayed as inhibitors of MMP-1, MMP-2, MMP-8 and MMP-9, and of the collagenase isolated from Clostridium histolyticum (ChC). Some of the new derivatives reported here proved to be powerful inhibitors of the four MMPs mentioned above and of ChC, with activities in the low nanomolar range for some of the target enzymes, depending on the substitution pattern at the sulfonylureido moiety and on the length of the spacer through which the dibenzosuberenyl/suberyl group is connected with the rest of the molecule. Several of these inhibitors also showed selectivity for the deep pocket enzymes (MMP-2, MMP-8 and MMP-9) over the shallow pocket ones MMP-1 and ChC.

Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance

The invention relates to pharmaceutical compositions containing novel nitrate esters, of which it was found that they are useful for the treatment of ischemiatic heart diseases, decompensatio cordis, myocardial infarction and hypertension.

CHEMISTRY AND KINETICS OF ARYL CARBENES IN METHANOL AT LOW TEMPERATURES.

The chemistry and kinetics of six aryl carbenes in polycrystalline methanol are reported. The kinetics were monitored by triplet ESR spectroscopy. Isotope effects were used heavily to probe reaction mechanisms. Several analogues to solution chemistry and kinetics were found. It is concluded that the singlet-triplet energy separation decreases as DBS greater than DPC greater than DBT greater than NC greater than Fl greater than DMA.