2976-84-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(METHYLAMINO)CYCLOHEXANONE HYDROCHLORIDE is used as an intermediate for the synthesis of muscle relaxants and antiepileptic medications, playing a crucial role in the development of these therapeutic agents.
Used in Agrochemical Industry:
4-(METHYLAMINO)CYCLOHEXANONE HYDROCHLORIDE is used as an intermediate in the synthesis of aspartate receptor antagonists, which are important in the development of agrochemicals for pest control and crop protection.
Used in Central Nervous System Research:
4-(METHYLAMINO)CYCLOHEXANONE HYDROCHLORIDE is used as a research compound in the study of the central nervous system, aiding in the understanding of its potential applications and effects on neurological functions.
Used in Pain Management Drug Development:
4-(METHYLAMINO)CYCLOHEXANONE HYDROCHLORIDE is used as a potential non-opioid analgesic in the research and development of new pain management drugs with reduced side effects, offering an alternative to traditional opioid-based pain medications.

InChI:InChI=1/C7H13NO/c1-8-6-2-4-7(9)5-3-6/h6,8H,2-5H2,1H3

Upstream product

• 22348-44-3 trans-4-Methylamino-cyclohexanol 
• 22906-85-0 4-methylamino-phenol; hydrochloride 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 593-51-1 methylamine hydrochloride 
• 166398-41-0 4-(N-methyl)aminocyclohexane ethylene acetal 

Downstream Products

• 2976-83-2 4--cyclohexanon 
• 82323-66-8 (+/-)-N-benzoyl-4-methylaminocycloheptanone 
• 1297611-94-9 4-(1H-Indol-3-yl)-N-methylcyclohex-3-enamine 
• 1312333-18-8 C₂₆H₄₁N₃ 
• 400899-84-5 tert-butyl N-methyl-N-(4-oxocyclohexyl)carbamate 
• 1086380-08-6 tert-butyl N-(trans-4-hydroxy-4-methylcyclohexyl)-N-methylcarbamate 
• 1086380-05-3 tert-butyl N-(cis-4-hydroxy-4-methylcyclohexyl)-N-methylcarbamate 
• 1086378-49-5 N-(cis-4-hydroxy-4-methylcyclohexyl)-N-methyl-2,1,3-benzoxadiazole-5-carboxamide 
• 2976-82-1 4--2,2,6,6-tetra-<2-cyan-aethyl>-cyclohexanon 
• 2976-88-7 4-Methylamino-2,2,6,6-tetra-<2-cyan-aethyl>-cyclohexanon 

Relevant academic research and scientific papers

A palladium/norbornene cooperative catalysis to access N-containing bridged scaffolds

A palladium/norbornene cooperative catalysis promoted annulation involving an ortho-C-H amination and intramolecular Heck cascade between aryl iodides and functionalized amination reagents is reported, thereby providing a highly convergent access to the u

Synthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones

An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-typ

Biotin tethered homotryptamine derivatives: High affinity probes of the human serotonin transporter (hSERT)

Quantum dot conjugates of compounds capable of inhibiting the serotonin transporter (SERT) could form the basis of fluorescent probes for live cell imaging of membrane bound SERT. Additionally, quantum dot-SERT antagonist conjugates may be amenable to flu

DI-SUBSTITUTED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES

This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke- induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

Method for preparing aromatic secondary amino compound

Disclosed are (1) a method for preparing an aromatic secondary amino compound which comprises reacting an N-cyclohexylideneamino compound in the presence of a hydrogen moving catalyst and a hydrogen acceptor by the use of a sulfur-free polar solvent and/or a cocatalyst, and (2) a method for preparing an aromatic secondary amino compound which comprises reacting cyclohexanone or a nucleus-substituted cyclohexanone, an amine and a nitro compound corresponding to the amine in a sulfur-free polar solvent in the presence of a hydrogen moving catalyst, a cocatalyst being added or not added. In a further aspect, a method is provided for the preparation of aminodiphenylamine by reacting phenylenediamine and cyclohexanone in the presence of a hydrogen transfer catalyst in a sulfur-free polar solvent while using nitroaniline as a hydrogen acceptor.

Method for preparing aromatic secondary amino compound

Disclosed are (1) a method for preparing an aromatic secondary amino compound which comprises reacting an N-cyclohexylideneamino compound in the presence of a hydrogen moving catalyst and a hydrogen acceptor by the use of a sulfur-free polar solvent and/or a cocatalyst, and (2) a method for preparing an aromatic secondary amino compound which comprises reacting cyclohexanone or a nucleus-substituted cyclohexanone, an amine and a nitro compound corresponding to the amine in a sulfur-free polar solvent in the presence of a hydrogen moving catalyst, a cocatalyst being added or not added.