297754-70-2Relevant academic research and scientific papers
Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: Biological activity of RU79115
Musicki, Branislav,Periers, Anne-Marie,Laurin, Patrick,Ferroud, Didier,Benedetti, Yannick,Lachaud, Sylvette,Chatreaux, Fabienne,Haesslein, Jean-Luc,Iltis, Alain,Pierre, Christine,Khider, Jean,Tessot, Nicole,Airault, Marlene,Demassey, Jacques,Dupuis-Hamelin, Claudine,Lassaigne, Patrice,Bonnefoy, Alain,Vicat, Pascale,Klich, Michel
, p. 1695 - 1699 (2000)
A new series of coumarin inhibitors of DNA gyrase B bearing a N-propargyloxycarbamate at C-3' of various 5',5'-dialkylnoviose, including RU79115, were synthesised and their antibacterial activities have been delineated. Introduction of dialkyl substituents at 5'5'-position of noviose leads to coumarin analogues with improved in vitro and in vivo antibacterial activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
