297771-20-1

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 623-27-8 terephthalaldehyde, 
• 1121-60-4 pyridine-2-carbaldehyde 
• 539-48-0 p-xylylidenediamine 
• 623-24-5 1,4-bis(bromomethyl)benzene 

Downstream Products

• 298181-74-5 N-(2-nitrobenzenesulfonyl)-N,N'-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine 

Relevant academic research and scientific papers

An exploration into the amide-pseudo amide hydrogen bonding synthon between a new coformer with two primary amide groups and theophylline

A cocrystal between a new coformer with two primary amide groups, 2,2′-((1,4-phenylenebis(methylene))-bis((pyridin-2-ylmethyl)azanediyl))diacetamide (2-BPXG), and theophylline (THP) was selected as a model system to (a) demonstrate the presence of a rare amide-pseudo amide hydrogen bonding synthon in it and identify further the structural features by single crystal X-ray diffraction, and (b) establish its relevant physicochemical properties through a comparison with the coformer by Fourier-transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), differential thermal analysis (DTA), powder X-ray diffraction (PXRD), and hot stage microscopy (HSM). To the best of our knowledge, this is the first example where a coformer with two primary amide groups has been used to form the amide-pseudo amide hydrogen bonding synthon. The co-crystal (2-BPXG·4THP) crystallizes in the triclinic space group P1 with Z = 1, where the unit cell contains one 2-BPXG molecule and four THP molecules. Meanwhile, the coformer 2-BPXG crystallizes in the monoclinic space group P21/c with Z = 2 (the asymmetric unit contains half of the molecule). Surprisingly, only 2-BPXG (compared to other coformers with aliphatic spacers between the two alkyl nitrogen atoms), which does not form the amide-amide hydrogen bonding synthon within itself, paves the way for the formation of the amide-pseudo amide hydrogen bonding synthon R22(9) with THP. An overall 2D supramolecular network is formed in 2-BPXG through the interlinking of ladder-shaped layers (which are generated through strong hydrogen bonding between one of the N-H bonds and pyridine nitrogen) via strong hydrogen bonding between the other N-H bond and the carbonyl group of an adjacent molecule. On the other hand, the coformer with one primary amide group on each end generates a ladder-shaped layer in the cocrystal through hydrogen bonding interactions with THP molecules. These ladder-shaped layers are further connected via strong π-π (centroid to centroid distance: 3.68 ?) and weak C-H?O interactions between the THP molecules to form an overall 3D supramolecular network in the cocrystal. Hydrogen bond propensities, Hirshfeld surface analysis and quantitative crystal structure analysis of both coformer and cocrystal allowed us to understand the amide-pseudo amide hydrogen bonding synthon in detail.

A new class of solvatochromic material: Geometrically unsaturated Ni (II) complexes

A series of Ni(II) double stranded binuclear complexes were synthesized upon treating the Ni(II) salts with series of diamino-bis-pyridine ligands, L1H2-L4H2 in 1:1 stiochiometric ratio. The Ni(II) centers exist

A general one-step synthesis of multidentate (pyridylalkyl)amines from mono-, bis-, tris- and tetrakis(bromomethyl)benzenes: Potential ligands for supramolecular assembly

The synthesis of new multidentate nitrogen-containing ligands is of ongoing interest. In this report, the one-step syntheses of a series of (pyridylalkyl)amine derivatives is described. The reported compounds contain both pyridine rings and sp3-hybridized nitrogen as potential donor sites. The general synthetic method involves a room temperature reaction of mono-, bis-, tris-, or tetrakis(bromomethyl)benzenes with an excess of (pyridylmethyl)amine in tetrahydrofuran. The products can be purified by distillation, chromatography or recrystallization and are obtained in fair to good yields. The advantages of this synthetic method are the procedural simplicity and the ready availability of the starting materials. The applicability of these compounds in supramolecular chemistry is demonstrated by the reaction of two of the described ligands with silver(I) salts. Georg Thieme Verlag Stuttgart.

Chemokine receptor binding heterocyclic compounds

This invention relates to a novel class of heterocyclic compounds that bind chemokine receptors, inhibiting the binding of their natural ligands thereby. These compounds result in protective effects against infection by HIV through binding to chemokine receptors, including CXCR4 and CCR5, thus inhibiting the subsequent binding by these chemokines. The present invention provides a compound of Formula I wherein, W is a nitrogen atom and Y is absent or, W is a carbon atom and Y═H; R1to R7may be the same or different and are independently selected from hydrogen or straight, branched or cyclic C1-6alkyl; R8is a substituted heterocyclic group or a substituted aromatic group Ar is an aromatic or heteroaromatic ring each optionally substituted at single or multiple, non-linking positions with electron-donating or withdrawing groups; n and n′ are independently, 0-2; X is a group of the formula: Wherein, Ring A is an optionally substituted, saturated or unsaturated 5 or 6-membered ring, and P is an optionally substituted carbon atom, an optionally substituted nitrogen atom, sulfur or oxygen atom. Ring B is an optionally substituted 5 to 7-membered ring. Ring A and Ring B in the above formula can be connected to the group W from any position via the group V, wherein V is a chemical bond, a (CH2)n″group (where n″=0-2) or a C═O group. Z is, (1) a hydrogen atom, (2) an optionally substituted C1-6alkyl group, (3) a C0-6alkyl group substituted with an optionally substituted aromatic or heterocyclic group, (4) an optionally substituted C0-6alkylamino or C3-7cycloalkylamino group, (5) an optionally substituted carbonyl group or sulfonyl. These compounds further include any pharmaceutically acceptable acid addition salts and metal complexes thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof.