29785-47-5

Upstream product

• 67-56-1 methanol 
• 2973-19-5 2-hydroxy-5-nitrobenzyl chloride 
• 64-17-5 ethanol 

Downstream Products

• 111986-60-8 4-(5-bromo-2-pyrimidinyloxy)-3methoxymethylaniline 
• 111986-57-3 4-(5-bromo-2-pyrimidinyloxy)-3-methylaniline 
• 111986-24-4 1-[4-(5-Bromo-pyrimidin-2-yloxy)-3-methoxymethyl-phenyl]-3-(2-nitro-benzoyl)-urea 

Relevant academic research and scientific papers

NPY ANTAGONISTS, PREPARATION AND USES

The present invention concerns novel compounds, their preparation and their uses, therapeutic uses in particular. More specifically it concerns derivative compounds having at least two aromatic cycles, their preparation and their uses, in particular in the area of human or animal health. These compounds have an affinity for the biological receptors of neuropeptide Y, NPY, present in the central and peripheral nervous systems. The compounds of the invention are preferably NPY antagonists, and more particularly antagonists of sub-type NPY Y1, and can therefore be used for the therapeutic or prophylactic treatment of any disorder involving NPY. The present invention also concerns pharmaceutical compositions containing said compounds, their preparation and their uses, as well as treatment methods using said compounds.

1,3-Dihydroxybenzene derivatives and colorants containing said compounds

1,3-Dihydroxybenzene derivatives of general formula (I) or (Ia) or physiologically tolerated, water-soluble thereof wherein R′1 denotes substituted pyridyl group, a pyrimidyl group, a group of formula (IIa) or (IIIa) and the dyeing agents for keratin fibers containing these compounds.

Oxidation dye composition for keratinous fibres comprising a para-aminophenol, a meta-aminophenol and a 2-substituted para-aminophenol

The invention relates to a dyeing composition for keratinous fibers and in particular for human keratinous fibers such as hair, comprising, in a suitable medium for dyeing, at least one oxidation dye precursor chosen from 3-methyl-para-aminophenol, 2-methyl-para-aminophenol and 2-hydroxymethyl-para-aminophenol, and their addition salts with an acid; at least one coupling agent chosen from the 2-methyl-5-aminophenols of formula (I): STR1 in which R denotes hydrogen, methyl or ethyl or a β-hydroxyethyl or γ-hydroxypropyl group, and their addition salts with an acid; and as oxidation dye precursor, a para-aminophenol which is 2-substituted by a substituent which is different from methyl or hydroxymethyl, or one of its addition salts with an acid.

Methods for dyeing keratinous fibers with compositions which contain aminoindole couplers, oxidation dye precursors, and oxidizing agents at acid pHs

A method for dyeing keratin fibers, wherein a composition is applied to said fibers which contains, in a suitable dyeing medium, at least one coupler having formula (I) STR1 wherein R1 is hydrogen or alkyl; R2 and R3 are hydrogen, alkyl, COOR', where R' is alkyl or hydrogen; R4 is hydrogen, hydroxyalkyl, alkyl, polyhydroxyalkyl or acetyl or aminoalkyl wherein the amine may be mono- or disubstituted by alkyl; Z1 and Z2 are hydrogen, alkyl, hydroxy, halogen, alkoxy or a salt thereof; at least one precursor of an oxidation hair dye; and at least one oxidizing agent, the pH of the composition applied to the fibers being less than 7.

3-substituted para-aminophenols

The invention concerns the use of a 3-substituted para-aminophenol as an oxidation dye precursor for dyeing keratinous fibres, in particular human hair. The 3-substituted para-aminophenol has formula: STR1 where R1 represents alkyl, alkenyl, mono- or polyhydroxyalkyl, nitrile, cyanoalkyl, halogenoalkyl, aminoalkyl or alkoxyalkyl and R2 represents hydrogen, alkyl or mono- or polyhydroxyalkyl, provided that when R2 is hydrogen R1 is not methyl or trifluoromethyl, and to addition salts thereof with an acid. The invention also concerns dye compositions containing compound (I). The invention further concerns novel 3-substituted para-aminophenols.

Process for dyeing keratinous fibres with an alkaline composition containing para-aminophenols substituted in position 2 in combination with 6- or 7-hydroxindole

A process for dyeing keratinous fibres, wherein a mixture of at least one para-aminophenol of formula: STR1 in which, Y is oxygen or sulphur, R is alkyl, monohydroxyalkyl, polyhydroxyalkyl, or their acid addition salts, and 6-hydroxyindole, 7- hydroxyindole or mixtures thereof, is applied to the fibers, the colour being delayed at alkaline pH with an oxidising agent.

Process for dyeing keratinous fibers with 2,4-diamino-1,3-dimethoxybenzene at an acid ph and compositions employed

Process for dyeing keratinous fibres, especially human keratinous fibres such as the hair, characterised in that a composition containing, in a medium suitable for dyeing, at least 2,4-diamino-1,3-dimethoxybenzene as a coupler; an oxidation dye precursor; and an oxidising agent; is applied to these fibres, the pH of the composition applied to the fibres being less than 7.

2-substituted para-aminophenols and their use for dyeing keratinous fibres

2-Substituted para-aminophenols of general formula: STR1 where Y denotes oxygen or sulphur and R denotes a C1 -C6 alkyl, C1 -C6 hydroxyalkyl or C1 -C6 haloalkyl or a C2 -C6 polyhydroxyalkyl, provided that when Y=O, R is not methyl or ethyl and when Y=S, R is not ethyl; and dye composition containing one or more compounds of formula (I) where Y denotes an oxygen or sulphur atom and R is C1 -C6 alkyl, C1 -C6 hydroxyalkyl, C1 -C6 haloalkyl or C2 -C6 polyhydroxyalkyl.

N-benzoyl urea compounds, antitumorous compositions containing them

An N-benzoyl urea compound having the formula: STR1 wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is STR2 wherein Y1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxyca