29786-45-6

Basic information

• Product Name: 1-(4-Methoxyphenyl)cyclobutanecarbonitrile
• Synonyms: 1-(4-methoxyphenyl)cyclobutanecarbonitrile
• CAS NO: 29786-45-6
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.24
• Mol File: 29786-45-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-Methoxyphenyl)cyclobutanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methoxyphenyl)cyclobutanecarbonitrile(29786-45-6)
• EPA Substance Registry System: 1-(4-Methoxyphenyl)cyclobutanecarbonitrile(29786-45-6)

Safety Data

• Hazardous Substances Data: 29786-45-6(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxyphenyl)cyclobutanecarbonitrile is a chemical compound with the molecular formula C13H13NO, which consists of a cyclobutane ring with a phenyl group and a nitrile group. It is a colorless to pale yellow liquid that is used in organic synthesis and pharmaceutical research. 1-(4-Methoxyphenyl)cyclobutanecarbonitrile is a versatile intermediate in the production of various pharmaceuticals and agrochemicals. It has potential applications in the development of new drugs and materials due to its unique structure and reactivity. Additionally, it can be used as a building block in the synthesis of more complex molecules. However, it is important to handle this compound with caution due to its potential hazards and toxic properties. Overall, 1-(4-Methoxyphenyl)cyclobutanecarbonitrile is an important chemical with various applications in the fields of pharmaceuticals and materials science.

Upstream product

• 104-47-2 p-methoxybenzylnitrile 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 29786-55-8 1-(4-methoxyphenyl)cyclobutane-1-carboxamide 
• 61492-43-1 (2S,5R,6R)-6-{[1-(4-Methoxy-phenyl)-cyclobutanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 405063-18-5 C₁₂H₁₄O₂ 
• 39868-68-3 1-cyclobutyl-4-methoxybenzene 
• 29786-28-5 (<1-(p-Methoxyphenyl)cyclobutyl>carbonyl)carbamsaeuremethylester 
• 29770-41-0 <<1-(p-Methoxyphenyl)cyclobutyl>carbonyl>harnstoff 
• 29786-34-3 (<1-(p-Methoxyphenyl)cyclobutyl>carbonyl)carbamsaeureethylester 
• 29770-28-3 <1-(p-Methoxyphenyl)-cyclobutyl>-carbonylisocyanat 
• 50921-37-4 1-(4-methoxy-phenyl)-cyclobutanecarboxylic acid 

Relevant articles and documents

Synthesis method of arylcyclobutane compound

The present invention discloses a method for synthesizing an arylcyclobutane compound to 1eq phenylacetonitrile and 1.1eq 1-bromo-3-chloropropane as raw material, N,N- dimethylacetamide as a solvent, plus 2.5eq sodium hydride, under the protection of iner

Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same

The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017

Phase transfer alkylation of arylacetonitriles revisited

Phase transfer alkylations of phenylacetonitrile derivatives carried out in the presence of 60-75% aqueous KOH, instead of the typical 50% NaOH, provide substantial improvements in the overall yields and purity of products. Reactions with simple secondary alkyl halides, as well as cycloalkylations with 1,2- and 1,3-dihaloalkanes proceed with good yields. Increasing the concentration of base diminishes the formation of by-products from competitive β-elimination processes.