29790-17-8

Upstream product

• 77611-79-1 (Z)-5'-Formylisoneoxanthobilirubinsaeure-methylester 
• 77611-80-4 5-(4-ethyl-3-methyl-5-oxo-1,5-dihydropyrrol-2-ylidenemethyl)-3-(2-methoxycarbonylethyl)-4-methyl-1H-pyrrole-2-carboxylic acid, tert-butyl ester 
• 67967-24-2 (E)-5-<5-t-butoxycarbonyl-4-(2-methoxycarbonylethyl)-3-methyl-2-pyrrolylmethylene>-3-ethyl-1,5-dihydro-4-methyl-2H-pyrrol-2-one 
• 77611-78-0 3,3'-dimethyl-4-ethyl-5'-formyl-4'-(2-(methoxycarbonyl)ethyl)-5(1H)-pyrromethenone 
• 64-18-6 formic acid 

Relevant academic research and scientific papers

Synthesis of a series of mono-meso-arylmesoporphyrins III of biological interest and their biliverdin derivatives

Synthesis of a series of mono-meso-arylmesoporphyrins III using a MacDonald-type 2+2 condensation is described. In this method, the substituted 1,9-diformyldipyrromethane is treated with a dipyrromethane-1,9-dicarboxylic acid under acidic conditions. The 5-aryldipyrrolic unit was obtained by condensation of tert-butyl, ethyl, or benzyl 4-ethyl-3-methyl-1H-pyrrole-2- carboxylate with different aromatic aldehydes in the presence of 4-toluene-sulfonic acid. In order to obtain the corresponding mesobiliverdins, chemical oxidation of each mesoporphyrin was carried out. Each meso-arylmesoporphyrin rendered two isomeric arylbiliverdins, as the porphyrin meso-aryl bridge is not cleaved. Georg Thieme Verlag Stuttgart.

Syntheses of Bile Pigments, XII Synthesis of E,Z,Z-Configurated Biliverdins from 5(1H)-Pyrromethenones of the Same Configuration

(Z,Z,Z)- and (E,Z,Z)-mesobiliverdin IIIα dimethyl esters 4 are obtained by acid-catalyzed condensation of methyl 5'-(tert-butoxycarbonyl)isoneoxanthobilirubinate with methyl (Z)- and (E)-5'-formylisoneoxanthobilirubinate, respectively.