29802-24-2Relevant academic research and scientific papers
Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
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Page/Page column 34, (2008/12/07)
Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.
N-substituted-N'-substituted urea derivatives and pharmaceutical compositions containing the derivatives
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, (2008/06/13)
N-Substituted-N′-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF-α production inhibitory activity.
Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands
Brunner, Henri,Hankofer, Peter,Holzinger, Ulrich,Treittinger, Barbara,Schoenenberger, Helmut
, p. 35 - 44 (2007/10/02)
The synthesis of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described.The new compounds have been tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the CD2F1-mouse.In the P388 test, 53 of the 55 tested complexes fulfill the minimum activity of 125percent T/C required for a substance to be active.
