29618-17-5

Basic information

• Product Name: L-phenylalanine dimethylamide
• Synonyms: L-phenylalanine dimethylamide
• CAS NO: 29618-17-5
• Molecular Weight: 192.261
• Mol File: 29618-17-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: L-phenylalanine dimethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: L-phenylalanine dimethylamide(29618-17-5)
• EPA Substance Registry System: L-phenylalanine dimethylamide(29618-17-5)

Safety Data

• Hazardous Substances Data: 29618-17-5(Hazardous Substances Data)

Upstream product

• 78800-68-7 (S)-tert-butyl 1-(dimethylamino)-1-oxo-3-phenylpropan-2-ylcarbamate 
• 2578-84-9 p-nitrophenyl N-(benzyloxycarbonyl)-L-phenylalaninate 
• 124-40-3 dimethyl amine 
• 4375-83-1 tris(dimethylamino)borane 
• 63-91-2 L-phenylalanine 
• 119153-87-6 (C₅H₉O₂)C₉H₉NO(O)(CO₂C₂H₅) 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 1161-13-3 N-Cbz-L-Phe 
• 105500-29-6 N²-(benzyloxycarbonyl)-N¹,N¹-dimethyl-L-phenylalanin-amid 

Downstream Products

• 145232-11-7 Boc-Asp(OBn)-Phe-NMe₂ 
• 609367-15-9 (R)-2-[(Benzyloxy-formyl-amino)-methyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2-phenyl-ethyl)-amide 
• 1351960-32-1 L-Phe-dimethylamide-isothiocyanate 
• 1351960-33-2 C₁₆H₂₅N₅O₂S 
• 1438263-84-3 (S)-N-(4-bromobenzyl)-N,N-dimethyl-2-(3-(4-nitrophenyl)thioureido)-3-phenylpropan-1-ammonium bromide 
• 1352966-64-3 (S,E)-2-(benzylideneamino)-N,N-dimethyl-3-phenylpropanamide 
• 1308661-88-2 2-(3-{[(2,3-difluoro-6-methoxy-benzyl)-((S)-1-dimethylaminomethyl-2-phenyl-ethyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid((1S,2S,3S,5R)-2,6,6-trimethyl-bicyclo[3.1.1]hept-3-yl)-amide 
• 1308661-80-4 2-(3-{[(6-chloro-2-fluoro-3-methoxy-benzyl)-((S)-1-dimethylaminomethyl-2-phenyl-ethyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ((1S,2S,3S,5R)-2,6,6-trimethyl-bicyclo[3.1.1]hept-3-yl)-amide 
• 1308662-10-3 2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ((1S,2S,3S,5R)-2,6,6-trimethyl-bicyclo[3.1.1]hept-3-yl)amide 
• 1308662-09-0 2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid 
• 1308662-08-9 2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester 
• 1000072-68-3 (2S)-N,N-dimethyl-3-phenyl-2-((3-phenylaziridin-2-yl)methylamino)propanamide 
• 186430-66-0 S-3-Bromo-5-chloro-1H-indole-2-carboxylic acid (1-dimethyl-carbamoyl-2-phenyl-ethyl)-amide 
• 29802-24-2 2-amino-1,1-N-dimethylamino-3-phenylpropane 

Relevant articles and documents

Asymmetric hydroazidation of α-substituted vinyl ketones catalyzed by chiral primary amine

We report herein the first example of asymmetric hydroazidation of α-substituted vinyl ketones by using chiral primary amines as the catalysts. A simple chiral primary-tertiary diamine catalyst derived from L-phenylalanine was found to readily promote this aza-Michael addition reaction with enamine protonation as the key stereogenic step, thus enabling the effective synthesis of α-chiral β-azido ketones with good yields and moderate enantioselectivities.

Novel bifunctional thiourea-ammonium salt catalysts derived from amino acids: Application to highly enantio- and diastereoselective aza-Henry reaction

The development of new efficient and easily accessible catalysts has been one of the focuses in asymmetric phase-transfer catalysis. In this paper, a novel class of chiral bifunctional thiourea-ammonium phase-transfer catalysts were synthesized from commercially available α-amino acids. The structural modularity of these catalysts permits facile tunings to achieve optimum results, which was demonstrated in catalyzing the aza-Henry reaction with excellent enantioselectivities (up to 99.5% ee) and diastereoselectivities (up to >25:1 dr).

SULTAM DERIVATIVES

The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.