298181-83-6

Basic information

• Product Name: 5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE
• Synonyms: 5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE;5,6,7,8-TETRAHYDRO-QUINOLIN-8-YLAMINE;AKOS BB-8710;8-Quinolinamine,5,6,7,8-tetrahydro-(9CI);8-quinolinamine,5,6,7,8-tetrahydro;5,6,7,8-Tetrahydro-8-quinolinamine;8-AMino-5,6,7,8-tetrahydroquinoline;5,6,7,8-tetrahydroquinolin-2-amine
• CAS NO: 298181-83-6
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.2
• Product Categories: PYRIDINE;AMINEPRIMARY;Quinoline Derivertives
• Mol File: 298181-83-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 277.3 °C at 760 mmHg
• Flash Point: 146 °C
• Appearance: /
• Density: 1.081 g/cm³
• Vapor Pressure: 0.00456mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.93±0.20(Predicted)
• CAS DataBase Reference: 5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE(298181-83-6)
• EPA Substance Registry System: 5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE(298181-83-6)

Safety Data

• Hazardous Substances Data: 298181-83-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 33, p. 3497, 2003 DOI: 10.1081/SCC-120024729

InChI:InChI=1/C9H12N2/c10-8-5-1-3-7-4-2-6-11-9(7)8/h2,4,6,8H,1,3,5,10H2

Upstream product

• 1431726-92-9 8-amino-5,6,7,8-tetrahydroquinoline hydrochloride 
• 14631-46-0 5,6,7,8-tetrahydroquinoline-8-ol 
• 56826-69-8 5,6,7,8-tetrahydro-8-quinolinone 
• 477531-98-9 N-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide 
• 125163-05-5 8-hydroxy-4-methoxy-5,6,7,8-tetrahydroquinoline 
• 1374781-10-8 8-azido-5,6,7,8-tetrahydroquinoline 
• 502612-35-3 (R)-N-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide 
• 10500-57-9 5,6,7,8-tetrahydroquinoline 
• 58509-59-4 6,7-dihydro-5H-quinolin-8-one oxime 
• 369655-84-5 (R)-(-)-8-amino-5,6,7,8-tetrahydroquinoline 

Downstream Products

• 298181-94-9 2-nitro-N-(5,6,7,8-tetrahydro-quinolin-8-yl)-benzenesulfonamide 
• 1059145-38-8 N'-phenyl-4-((5,6,7,8-tetrahydroquinolin-8-ylamino)methyl)benzohydrazide 
• 405230-56-0 C₂₂H₂₂N₄O 
• 298181-84-7 N-(2-nitrobenzenesulfonyl)-N-(2-pyridinylmethyl)-N'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine 
• 405175-08-8 3-[(5,6,7,8-tetrahydroquinolin-8-ylamino)methyl]benzonitrile 
• 405174-87-0 4-[(5,6,7,8-tetrahydroquinolin-8-ylamino)methyl]benzonitrile 
• 1059147-29-3 boc-protected-4-((((1H-benzo[d]imidazol-2-yl)methyl)(5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-N'-phenylbenzohydrazide 
• 1059145-41-3 4-((((1H-benzo[d]imidazol-2-yl)methyl)(5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)-N'-phenylbenzohydrazide 
• 405230-59-3 Pyridine-2-sulfonic acid 4-[(5,6,7,8-tetrahydro-quinolin-8-ylamino)-methyl]-benzylamide 
• 405230-00-4 N-(4-((5,6,7,8-tetrahydroquinolin-8-ylamino)methyl)benzyl)picolinamide 
• 405229-93-8 N-pyridin-2-ylmethyl-4-[(5,6,7,8-tetrahydro-quinolin-8-ylamino)-methyl]-benzenesulfonamide 
• 477531-98-9 N-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide 
• 369655-84-5 (R)-(-)-8-amino-5,6,7,8-tetrahydroquinoline 
• 369656-57-5 (S)-(+)-8-amino-5,6,7,8-tetrahydroquinoline 

Relevant articles and documents

Convenient synthesis of 5,6,7,8-tetrahydroquinolin-8-ylamine and 6,7-dihydro-5H-quinolin-8-one

A novel two-step synthesis of 5,6,7,8-tetrahydroquinolin-8-ylamine, involving regioselective nitrosation of 5,6,7,8-tetrahydroquinoline followed by oxime reduction, is described. Oxime hydrolysis affords 6,7-dihydro-5H-quinolin-8-one.

CXCR2 ANTAGONIST

A compound as a CXCR2 antagonist and an application thereof in preparing a drug as a CXCR2 antagonist. In particular, the present invention relates to a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

Multi-substituted amine compound and its preparation and use (by machine translation)

The invention belongs to the field of medical technology, in particular, the present invention provides the following formula I shown multi-substituted amine compound or its isomer or its pharmaceutically acceptable salt, ester, prodrug or hydrate, its pharmaceutical composition, preparation method thereof and its use in the preparation of medicine for treating aids in use. The compound or pharmaceutical composition containing the compound can be used as an inhibitor for inhibiting HIV integrase with LEDGF/p75 between protein - protein interaction and HIV integrase dimerization, then can be used for the treatment of aids. . (by machine translation)