298183-97-8

Upstream product

• 2439-37-4 (S)-2-dimethylamino-4-methyl-pentanoic acid 
• 216229-02-6 (2R,3S)-1-(tert-butoxycarbonyl)-2-[(tert-butyldimethylsilyloxy)methyl]-3-hydroxypyrrolidine 
• 42298-41-9 5-iodo-2-methoxy-benzaldehyde 
• 90-02-8 salicylaldehyde 
• 1761-62-2 5-iodosalicyclaldehyde 
• 929896-12-8 C₂₀H₂₇N₃O₄ 
• 929896-08-2 C₂₅H₃₅N₃O₆ 
• 929896-09-3 (2R,3S)-{1-(tert-butoxycarbonyl)-3-[3-((Z)-2-iodovinyl)-4-methoxy-phenoxy]-prolyl}-isoleucinamide 
• 929896-15-1 (2R,3S)-1-(tert-butoxycarbonyl)-3-[3-((Z)-2-iodovinyl)-4-methoxy-phenoxy]-proline 
• 929896-14-0 (2R,3S)-1-(tert-butoxycarbonyl)-2-formyl-3-[3-((Z)-2-iodovinyl)-4-methoxy-phenoxy]-pyrrolidine 
• 929896-13-9 (2R,3S)-1-(tert-butoxycarbonyl)-2-hydroxymethyl-3-[3-((Z)-2-iodovinyl)-4-methoxy-phenoxy]-pyrrolidine 
• 929896-11-7 (2R,3S)-1-(tert-butoxycarbonyl)-2-(tert-butyldimethylsilyloxy)methyl-3-[3-((Z)-2-iodovinyl)-4-methoxy-phenoxy]-pyrrolidine 
• 929896-10-6 (2R,3S)-1-(tert-butoxycarbonyl)-2-(tert-butyldimethylsilyloxy)methyl-3-(3-formyl-4-methoxy-phenoxy)-pyrrolidine 
• 37174-12-2 (2S,3S)-2-(dimethylamino)-3-methylpentanoic acid 

Relevant academic research and scientific papers

A general route to cyclopeptide alkaloids: total syntheses and biological evaluation of paliurines e and F, ziziphines N and Q, abyssenine A, mucronine E, and analogues

A full account of the total syntheses of the cyclopeptide alkaloids paliurine E and F, ziziphine N and Q, abyssenine A, and mucronine E is provided. A key feature of the syntheses involves an intramolecular amidation of a vinyl iodide, which allows us sim

Total synthesis of paliurine F

A couple of coppers: An efficient, asymmetric synthesis of the sedative cyclopeptide alkaloid paliurine F has been achieved. The strategy employs two copper(I)-mediated coupling reactions as key steps to install the aryl ether linkage as well as to form t