2983-42-8

Usage

Type of compound

Chemical compound

Uses

Production of pharmaceuticals and agrochemicals, potential use as a building block in organic synthesis, research purposes

Properties

Stability and solubility in aqueous solutions

Other notes

Versatile chemical with a range of applications in the chemical industry.

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 5625-90-1 4-(morpholinomethyl)morpholine 
• 52853-19-7 N-(methylene)morpholinium chloride 
• 1896-62-4 (E)-benzalacetone 

Downstream Products

• 73291-51-7 1-phenyl-1,4-pentadien-3-one 
• 1374446-66-8 (E)-5-(morpholin-4-yl)-1-phenylpent-1-en-3-one thiosemicarbazone hydrochloride 
• 132105-82-9 5-morpholino-1t-phenyl-pent-1-en-3-one-phenylhydrazone; hydrochloride 

Relevant academic research and scientific papers

An efficient water-mediated synthetic route for the alkylation of heteroarenes

An efficient synthetic route has been described for the alkylation of 1H-indole, 1H-benzimidazole, and 1H-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.

Evaluation of alkylating and intercalating properties of mannich bases for cytotoxic activity

A series of new "hybrid compounds", Mannich base derivatives of planar polycyclic/heterocyclic starting materials, was designed and synthesized. The structures of the compounds were confirmed by spectroscopic methods and elemental analysis. Cytotoxicity of compounds was investigated in three cancer cell lines (PC3, HeLa, and MCF7) and one non-tumoral cell line (293 HEK). We tested the DNA-intercalating capability of the molecules by ethidium bromide (EtBr) fluorescence displacement experiment. Compounds' alkylation potency was investigated via in vitro incubation test using 2-mercaptoethanol, a biomimetic nucleophile. The five of the compounds (7s, 9d, 10b, 11b, 12c) are reported for first time in the literature. Our results suggest that compound 9d has a biological activity close to the reference compound doxorubicin, an intercalating agent in clinical use.

Mannich Bases of 4-Phenyl-3-buten-2-one: A New Class of Antiherpes Agent

The morpholine Mannich base of 4-phenyl-3-buten-2-one was found to have activity in model infections of herpes simplex.The activity was essentially equivalent to that of disodium phosphonoacetate.This paper presents the biological activity and synthesis o

Antiviral 1-aryl-5-amino-1-penten-3-ones

Compounds of the formula STR1 wherein R is H, halo, C1-4 alkyl, C1-4 alkoxy, 3,4-methylenedioxy, CF3, NO2, NH2, N(C1-4 alkyl)2, CN, OH, --S(C1-4 alkyl) or --SO2/