29848-59-7

Usage

Uses

Used in Pharmaceutical Industry:
1-BROMO-3-(DIFLUOROMETHYL)BENZENE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines. Its unique structure allows for specific reactions that are crucial in the creation of complex organic molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 1-BROMO-3-(DIFLUOROMETHYL)BENZENE is employed as an intermediate in the production of agrochemicals, aiding in the development of pesticides and other agricultural chemicals that are essential for crop protection and yield enhancement.
Used in Dye Production:
1-BROMO-3-(DIFLUOROMETHYL)BENZENE is used as a building block in the creation of dyes, where its chemical properties are leveraged to produce a range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Polymer Production:
1-BROMO-3-(DIFLUOROMETHYL)BENZENE is also utilized in the synthesis of polymers, where it contributes to the formation of polymeric materials with specific properties, such as heat resistance or chemical stability, which are valuable in a wide array of industrial applications.

InChI:InChI=1/C7H5BrF2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,7H

Upstream product

• 368-99-0 3-difluoromethyl-phenylamine 
• 3429-52-5 2,2,3-trimethyl-2-silabutane 
• 591-18-4 1-Bromo-3-iodobenzene 
• 619-28-3 m-nitrobenzylidene chloride 
• 403-25-8 1-(difluoromethyl)-3-nitrobenzene 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 197145-32-7 (2RS,3RS)-3-(3-difluoromethyl-phenyl)-1-dimethylamino-2-methyl-pentan-3-ol hydrochloride 
• 1242446-34-9 methyl 8-(3-(difluoromethyl)phenyl)quinoline-2-carboxylate 

Relevant academic research and scientific papers

5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY

The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes

The budding deuteriodifluoromethyl group (CF2D) is a potentially significant functional group in medicinal chemistry. Herein, we investigated t-BuOK-catalyzed H/D exchange reaction of difluoromethylarenes in DMSO-d6 solution. The method provides excellent

NOVEL BENZYLAMINO SUBSTITUTED QUINAZOLINES AND DERIVATIVES AS SOS1 INHIBITORS

The present invention encompasses compounds of formula (I), wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Synthesis, reactivity, and catalytic applications of isolable (NHC)Cu(CHF2) complexes

Difluoromethyl copper complexes have been proposed as key intermediates in a variety of Cu-catalyzed difluoromethylation reactions. However, studies of these putative intermediates have been impeded by the low stability of these [Cu(CHF2)] species. This report describes the synthesis of isolable N-heterocyclic carbene ligated copper(I) difluoromethyl complexes. The stoichiometric reactions of these complexes with aryl electrophiles (i.e., diaryliodonium salts, aryl iodides, and aryl bromides) are described. In addition, Nheterocyclic carbene copper(I) species are demonstrated to serve as catalysts for the cross-coupling of aryl iodides with (difluoromethyl)trimethylsilane to afford difluoromethyl arene products.

Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride

We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.

TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE

The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

Substituted imidazol-pyridazine derivatives

The present invention relates to compounds of formula wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.

1-phenyl-3-dimethylaminopropane compounds with a pharmacological effect

1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.